Fuzzy logic selection as a new reliable tool to identify molecular grade signatures in breast cancer--the INNODIAG study.

Journal: BMC medical genomics
Published Date: Feb 7, 2015

Abstract

BACKGROUND: Personalized medicine has become a priority in breast cancer patient management. In addition to the routinely used clinicopathological characteristics, clinicians will have to face an increasing amount of data derived from tumor molecular profiling. The aims of this study were to develop a new gene selection method based on a fuzzy logic selection and classification algorithm, and to validate the gene signatures obtained on breast cancer patient cohorts.

Authors

  • Tatiana Kempowsky-Hamon
    CNRS, LAAS, F-31400, Toulouse, France. tatianak0417@gmail.com.
  • Carine Valle
    Université de Toulouse; INSA, UPS, INP; LISBP, F-31077, Toulouse, France. vallecarine@hotmail.com.
  • Magali Lacroix-Triki
    Institut Claudius Regaud, Biology and Pathology Department; INSERM UMR1037, Toulouse, France. Lacroix.Magali@claudiusregaud.fr.
  • Lyamine Hedjazi
    CNRS, LAAS, F-31400, Toulouse, France. hedjazil@hotmail.com.
  • Lidwine Trouilh
    Université de Toulouse; INSA, UPS, INP; LISBP, F-31077, Toulouse, France. lidwine.trouilh@insa-toulouse.fr.
  • Sophie Lamarre
    Université de Toulouse; INSA, UPS, INP; LISBP, F-31077, Toulouse, France. sophie.lamarre@insa-toulouse.fr.
  • Delphine Labourdette
    Université de Toulouse; INSA, UPS, INP; LISBP, F-31077, Toulouse, France. delphine.labourdette@insa-toulouse.fr.
  • Laurence Roger
    Institut Claudius Regaud, Biology and Pathology Department; INSERM UMR1037, Toulouse, France. Roger.Laurence@claudiusregaud.fr.
  • Loubna Mhamdi
    Institut Claudius Regaud, Biology and Pathology Department; INSERM UMR1037, Toulouse, France. Mhamdi.Loubna@claudiusregaud.fr.
  • Florence Dalenc
    Dendris SAS, 8 Rue de Cugnaux, 31300, Toulouse, France. Dalenc.Florence@claudiusregaud.fr.
  • Thomas Filleron
    Institut Claudius Regaud, Oncology Department, Toulouse, France. Filleron.Thomas@claudiusregaud.fr.
  • Gilles Favre
    Institut Claudius Regaud, Biology and Pathology Department; INSERM UMR1037, Toulouse, France. Favre.Gilles@claudiusregaud.fr.
  • Jean-Marie François
    Université de Toulouse; INSA, UPS, INP; LISBP, F-31077, Toulouse, France. fran_jm@insa-toulouse.fr.
  • Marie-Véronique Le Lann
    CNRS, LAAS, F-31400, Toulouse, France. mvlelann@laas.fr.
  • Véronique Anton-Leberre
    Université de Toulouse; INSA, UPS, INP; LISBP, F-31077, Toulouse, France. leberre@insa-toulouse.fr.

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