Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression.

Journal: Molecular autism
PMID: 26985359

Abstract

BACKGROUND: Intellectual disability (ID), autism, and epilepsy share frequent yet variable comorbidities with one another. In order to better understand potential genetic divergence underlying this variable risk, we studied genes responsible for monogenic IDs, grouped according to their autism and epilepsy comorbidities.

Authors

  • Emily L Casanova
    Department of Biomedical Sciences, University of South Carolina, South Carolina, USA ; Department of Pediatrics, Greenville Health System, Patewood Medical Campus, 200A Patewood Dr, Greenville, SC 29615 USA.
  • Julia L Sharp
    Department of Mathematical Sciences, Clemson University, Clemson, USA.
  • Hrishikesh Chakraborty
    Department of Biostatistics and Epidemiology, University of South Carolina, South Carolina, USA.
  • Nahid Sultana Sumi
    Department of Biostatistics and Epidemiology, University of South Carolina, South Carolina, USA.
  • Manuel F Casanova
    Department of Biomedical Sciences, University of South Carolina, South Carolina, USA ; Department of Pediatrics, Greenville Health System, Patewood Medical Campus, 200A Patewood Dr, Greenville, SC 29615 USA.

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