BACKGROUND: Thoracic SMARCA4-deficient undifferentiated tumors (SMARCA4-UT) exhibit a notably aggressive phenotype, which is associated with poor patient survival outcomes. These tumors are generally resistant to conventional cytotoxic chemotherapy, ...
Microcystins (MC) represent a family of cyclic peptides with approx. 250 congeners presumed harmful to human health due to their ability to inhibit ser/thr-proteinphosphatases (PPP), albeit all hazard and risk assessments (RA) are based on data of on...
Computational intelligence and neuroscience
35909838
This paper solves the problem of difficulty in achieving satisfactory results with traditional methods of bearing fault diagnosis, which can effectively extract the fault information and improve the fault diagnosis accuracy. This paper proposes a nov...
One of the most important tasks in remote sensing image analysis is remote sensing image Change Detection (CD), and CD is the key to helping people obtain more accurate information about changes on the Earth's surface. A Multi-Attention Guided Featur...
DNA methylation is a process that can affect gene accessibility and therefore gene expression. In this study, a machine learning pipeline is proposed for the prediction of breast cancer and the identification of significant genes that contribute to t...
Mammalian genomes have multiple enhancers spanning an ultralong distance (>megabases) to modulate important genes, but it is unclear how these enhancers coordinate to achieve this task. We combine multiplexed CRISPRi screening with machine learning t...
UNLABELLED: Intratumoral heterogeneity arising from tumor evolution poses significant challenges biologically and clinically. Dissecting this complexity may benefit from deep learning (DL) algorithms, which can infer molecular features from ubiquitou...
Asian Pacific journal of cancer prevention : APJCP
37774049
OBJECTIVE: In India, usually, oral cancer is mostly identified at a progressive stage of malignancy. Hence, we are motivated to identify oral cancer in its early stages, which helps to increase the lifetime of the patient, but this early detection is...
Bromodomain 4 and 9 (BRD4 and BRD9) have been regarded as important targets of drug designs in regard to the treatment of multiple diseases. In our current study, molecular dynamics (MD) simulations, deep learning (DL) and binding free energy calcula...