Accelerated partial breast irradiation using robotic radiotherapy: a dosimetric comparison with tomotherapy and three-dimensional conformal radiotherapy.

Journal: Radiation oncology (London, England)
Published Date: Feb 27, 2016

Abstract

BACKGROUND: Accelerated partial breast irradiation (APBI) is a new breast treatment modality aiming to reduce treatment time using hypo fractionation. Compared to conventional whole breast irradiation that takes 5 to 6 weeks, APBI is reported to induce worse cosmetic outcomes both when using three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT). These late normal tissue effects may be attributed to the dose volume effect because a large portion of the non-target breast tissue volume (NTBTV) receives a high dose. In the context of APBI, non-coplanar beams could spare the NTBTV more efficiently. This study evaluates the dosimetric benefit of using the Cyberknife (CK) for APBI in comparison to IMRT (Tomotherapy) and three dimensional conformal radiotherapy (3D-CRT).

Authors

  • Erwann Rault
    Academic Department of Radiation Oncology, Centre Oscar Lambret, 3 rue Frédéric Combemale, BP 307, 59020, LILLE Cedex, France. e-rault@o-lambret.fr.
  • Thomas Lacornerie
    Academic Department of Radiation Oncology, Centre Oscar Lambret, 3 rue Frédéric Combemale, BP 307, 59020, LILLE Cedex, France. t-lacornerie@o-lambret.fr.
  • Hong-Phuong Dang
    Academic Department of Radiation Oncology, Centre Oscar Lambret, 3 rue Frédéric Combemale, BP 307, 59020, LILLE Cedex, France. hong_phuong.dang@ec-lille.fr.
  • Frederik Crop
    Academic Department of Radiation Oncology, Centre Oscar Lambret, 3 rue Frédéric Combemale, BP 307, 59020, LILLE Cedex, France. f-crop@o-lambret.fr.
  • Eric Lartigau
    Academic Department of Radiation Oncology, Centre Oscar Lambret, 3 rue Frédéric Combemale, BP 307, 59020, LILLE Cedex, France. e-lartigau@o-lambret.fr.
  • Nick Reynaert
    Academic Department of Radiation Oncology, Centre Oscar Lambret, 3 rue Frédéric Combemale, BP 307, 59020, LILLE Cedex, France. n-reynaert@o-lambret.fr.
  • David Pasquier
    Academic Department of Radiation Oncology, Centre Oscar Lambret, 3 rue Frédéric Combemale, BP 307, 59020, LILLE Cedex, France. d-pasquier@o-lambret.fr.

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