Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study.

Journal: The American journal of psychiatry
Published Date: Feb 26, 2016

Abstract

OBJECTIVE: Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a fundamentally different process? The authors used support vector regression, a supervised machine learning technique, to address this question.

Authors

  • Hugo G Schnack
    From the Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht.
  • Neeltje E M van Haren
    From the Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht.
  • Mireille Nieuwenhuis
    From the Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht.
  • Hilleke E Hulshoff Pol
    Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.
  • Wiepke Cahn
    From the Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht.
  • RenĂ© S Kahn
    Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.

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