Dosimetric study on learning-based cone-beam CT correction in adaptive radiation therapy.

Journal: Medical dosimetry : official journal of the American Association of Medical Dosimetrists
Published Date: Apr 1, 2019

Abstract

INTRODUCTION: Cone-beam CT (CBCT) image quality is important for its quantitative analysis in adaptive radiation therapy. However, due to severe artifacts, the CBCTs are primarily used for verifying patient setup only so far. We have developed a learning-based image quality improvement method which could provide CBCTs with image quality comparable to planning CTs (pCTs). The accuracy of dose calculations based on these CBCTs is unknown. In this study, we aim to investigate the dosimetric accuracy of our corrected CBCT (CCBCT) in brain stereotactic radiosurgery (SRS) and pelvic radiotherapy.

Authors

  • Tonghe Wang
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322.
  • Yang Lei
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322.
  • Nivedh Manohar
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322.
  • Sibo Tian
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
  • Ashesh B Jani
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
  • Hui-Kuo Shu
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322.
  • Kristin Higgins
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
  • Anees Dhabaan
    Department of Radiation Oncology, Emory University, 1365 Clifton Road NE, Department of Radiation Oncology, Atlanta, Atlanta, Georgia, 30322, UNITED STATES.
  • Pretesh Patel
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
  • Xiangyang Tang
    Department of Radiology and Imaging Sciences and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
  • Tian Liu
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
  • Walter J Curran
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322.
  • Xiaofeng Yang
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

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