Breast cancer outcome prediction with tumour tissue images and machine learning.

Journal: Breast cancer research and treatment
Published Date:

Abstract

PURPOSE: Recent advances in machine learning have enabled better understanding of large and complex visual data. Here, we aim to investigate patient outcome prediction with a machine learning method using only an image of tumour sample as an input.

Authors

  • Riku Turkki
    Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. riku.turkki@helsinki.fi.
  • Dmitrii Byckhov
    Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Mikael Lundin
    Institute for Molecular Medicine Finland, HILIFE, University of Helsinki, Helsinki, Finland.
  • Jorma Isola
    Department of Cancer Biology, BioMediTech, University of Tampere, Tampere, Finland.
  • Stig Nordling
    Department of Pathology, Medicum, University of Helsinki, Helsinki, Finland.
  • Panu E Kovanen
    HUSLAB and Medicum, Helsinki University Hospital Cancer Center and University of Helsinki, Helsinki, Finland.
  • Clare Verrill
    Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK; Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. Electronic address: Clare.Verrill@ouh.nhs.uk.
  • Karl von Smitten
    Eira Hospital, Helsinki, Finland.
  • Heikki Joensuu
    Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Johan Lundin
    Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Nina Linder
    Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.