Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images.

Journal: Cancer medicine
PMID: 32400056

Abstract

BACKGROUND: It is unclear whether clinical factors and immune microenvironment (IME) factors are associated with tumor mutation burden (TMB) in patients with nonsmall cell lung cancer (NSCLC).

Authors

  • Akira Ono
    Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Yukihiro Terada
    Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
  • Takuya Kawata
    Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Masakuni Serizawa
    Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, Shizuoka Cancer Center, Shizuoka, Japan.
  • Mitsuhiro Isaka
    Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
  • Takanori Kawabata
    Clinical Research Center, Shizuoka Cancer Center, Shizuoka, Japan.
  • Toru Imai
    Department of Clinical Biostatistics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Keita Mori
  • Koji Muramatsu
    Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Isamu Hayashi
    Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Hirotsugu Kenmotsu
    Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Keiichi Ohshima
    Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka Cancer Center, Shizuoka, Japan.
  • Kenichi Urakami
    Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka Cancer Center, Shizuoka, Japan.
  • Takeshi Nagashima
    Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka Cancer Center, Shizuoka, Japan.
  • Masatoshi Kusuhara
    Region Resources Division, Shizuoka Cancer Center Research Institute, Shizuoka Cancer Center, Shizuoka, Japan.
  • Yasuto Akiyama
    Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka Cancer Center, Shizuoka, Japan.
  • Takashi Sugino
    Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Yasuhisa Ohde
    Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
  • Ken Yamaguchi
    Shizuoka Cancer Center, Shizuoka, Japan.
  • Toshiaki Takahashi
    Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Keywords

External Resources

Popular Topics
Recent Journals