Preprocedure Application of Machine Learning and Mechanistic Simulations Predicts Likelihood of Paroxysmal Atrial Fibrillation Recurrence Following Pulmonary Vein Isolation.

Journal: Circulation. Arrhythmia and electrophysiology
PMID: 32536204

Abstract

BACKGROUND: Pulmonary vein isolation (PVI) is an effective treatment strategy for patients with atrial fibrillation (AF), but many experience AF recurrence and require repeat ablation procedures. The goal of this study was to develop and evaluate a methodology that combines machine learning (ML) and personalized computational modeling to predict, before PVI, which patients are most likely to experience AF recurrence after PVI.

Authors

  • Julie K Shade
    Alliance for Cardiovascular Diagnostic and Treatment Innovation (ADVANCE), Johns Hopkins University, Baltimore, Maryland.
  • Rheeda L Ali
    Alliance for Cardiovascular Diagnostic and Treatment Innovation (J.K.S., R.L.A., D.B., D.P., H.C., N.A.T.), Johns Hopkins University, Baltimore, MD.
  • Dante Basile
    Alliance for Cardiovascular Diagnostic and Treatment Innovation (J.K.S., R.L.A., D.B., D.P., H.C., N.A.T.), Johns Hopkins University, Baltimore, MD.
  • Dan Popescu
    Faculty of Automatic Control and Computers, National University of Science and Technology Politehnica Bucharest, Bucharest, Romania.
  • Tauseef Akhtar
    Division of Cardiology, Department of Medicine (T.A., J.E.M., D.D.S., H.C.), Johns Hopkins University School of Medicine, Baltimore, MD.
  • Joseph E Marine
    Hypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
  • David D Spragg
    Division of Cardiology, The Johns Hopkins Hospital, Baltimore, MD (C.J.P., S.S., D.D.S.).
  • Hugh Calkins
    Alliance for Cardiovascular Diagnostic and Treatment Innovation (J.K.S., R.L.A., D.B., D.P., H.C., N.A.T.), Johns Hopkins University, Baltimore, MD.
  • Natalia A Trayanova
    Alliance for Cardiovascular Diagnostic and Treatment Innovation (ADVANCE), Johns Hopkins University, Baltimore, Maryland.

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