Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death.

Journal: Circulation research
PMID:

Abstract

RATIONALE: Susceptibility to VT/VF (ventricular tachycardia/fibrillation) is difficult to predict in patients with ischemic cardiomyopathy either by clinical tools or by attempting to translate cellular mechanisms to the bedside.

Authors

  • Albert J Rogers
    Cardiovascular Institute and Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
  • Anojan Selvalingam
    Department of Medicine and Cardiovascular Institute (A.J.R., A.S., M.I.A., T.B., P.C., P.J.W., S.M.N.), Stanford University.
  • Mahmood I Alhusseini
    Department of Medicine (M.I.A., A.J.R., J.A.B.Z., T.B., P.C., P.J.W., S.M.N.), Stanford University.
  • David E Krummen
    Department of Medicine (D.E.K.), University of California, San Diego.
  • Cesare Corrado
    King's College London, London, United Kingdom.
  • Firas Abuzaid
    Department of Computer Science (F.A., P.B., M.Z.), Stanford University.
  • Tina Baykaner
    Department of Medicine (M.I.A., A.J.R., J.A.B.Z., T.B., P.C., P.J.W., S.M.N.), Stanford University.
  • Christian Meyer
    Department of Social Medicine and Prevention, University Medicine Greifswald, Greifswald, Germany; Partner site Greifswald, DZHK (German Centre for Cardiovascular Research), Greifswald, Germany. Electronic address: chmeyer@uni-greifswald.de.
  • Paul Clopton
    Department of Medicine (M.I.A., A.J.R., J.A.B.Z., T.B., P.C., P.J.W., S.M.N.), Stanford University.
  • Wayne Giles
    Department of Physiology and Pharmacology, University of Calgary, Canada (W.G.).
  • Peter Bailis
    Department of Computer Science (F.A., P.B., M.Z.), Stanford University.
  • Steven Niederer
    Department of Biomedical Engineering, King's College London, United Kingdom (C.C., S.N.).
  • Paul J Wang
    Department of Medicine (M.I.A., A.J.R., J.A.B.Z., T.B., P.C., P.J.W., S.M.N.), Stanford University.
  • Wouter-Jan Rappel
    Department of Physics, University of California, San Diego (W.-J.R.).
  • Matei Zaharia
    Department of Computer Science (F.A., P.B., M.Z.), Stanford University.
  • Sanjiv M Narayan
    Biomedical Informatics Training Program (L.H., S.M.N.), Stanford University, CA.