Multimodal Machine Learning Workflows for Prediction of Psychosis in Patients With Clinical High-Risk Syndromes and Recent-Onset Depression.

Journal: JAMA psychiatry
Published Date:

Abstract

IMPORTANCE: Diverse models have been developed to predict psychosis in patients with clinical high-risk (CHR) states. Whether prediction can be improved by efficiently combining clinical and biological models and by broadening the risk spectrum to young patients with depressive syndromes remains unclear.

Authors

  • Nikolaos Koutsouleris
    Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
  • Dominic B Dwyer
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany;
  • Franziska Degenhardt
    Institute of Human Genetics, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
  • Carlo Maj
    Institute of Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany.
  • Maria Fernanda Urquijo-Castro
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany.
  • Rachele Sanfelici
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Munich, Germany.
  • David Popovic
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany.
  • Oemer Oeztuerk
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany.
  • Shalaila S Haas
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Johanna Weiske
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany.
  • Anne Ruef
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany.
  • Lana Kambeitz-Ilankovic
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany; These authors contributed equally. Lana.Kambeitz-Ilankovic@med.uni-muenchen.de.
  • Linda A Antonucci
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universität, Munich, Germany. linda.antonucci@med.uni-muenchen.de.
  • Susanne Neufang
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Christian Schmidt-Kraepelin
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Stephan Ruhrmann
    Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Nora Penzel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians Universität, Munich, Germany.
  • Joseph Kambeitz
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany;
  • Theresa K Haidl
    Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Marlene Rosen
    Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.
  • Katharine Chisholm
    Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom.
  • Anita Riecher-Rössler
    Department of Psychiatry, University of Basel, Basel, Switzerland.
  • Laura Egloff
    Department of Psychiatry, Psychiatric University Hospital, University of Basel, Switzerland.
  • André Schmidt
    Department of Psychiatry, Psychiatric University Hospital, University of Basel, Switzerland.
  • Christina Andreou
    Department of Psychiatry and Psychotherapy, University Hospital Lübeck (UKSH), Ratzeburger Allee 160, 23538 Lübeck, Germany.
  • Jarmo Hietala
    Department of Psychiatry, University of Turku, Turku, Finland.
  • Timo Schirmer
    GE Healthcare GmbH (previously GE Global Research GmbH), Munich, Germany.
  • Georg Romer
    Department of Child and Adolescent Psychiatry, University of Münster, Münster, Germany.
  • Petra Walger
    Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, LVR Clinic Düsseldorf, Düsseldorf, Germany.
  • Maurizia Franscini
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Zürich, Zürich, Switzerland.
  • Nina Traber-Walker
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Zürich, Zürich, Switzerland.
  • Benno G Schimmelmann
    University Hospital of Child and Adolescent Psychiatry, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
  • Rahel Flückiger
    University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
  • Chantal Michel
    University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
  • Wulf Rössler
    Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Zurich, Switzerland.
  • Oleg Borisov
    Institute of Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany.
  • Peter M Krawitz
    Institute for Genomic Statistic and Bioinformatics, University Hospital Bonn, Rheinische-Friedrich-Wilhelms University, Bonn, Germany.
  • Karsten Heekeren
    Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Zurich, Switzerland.
  • Roman Buechler
    Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Zurich, Switzerland.
  • Christos Pantelis
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, VIC, Australia.
  • Peter Falkai
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany;
  • Raimo K R Salokangas
    Department of Psychiatry, University of Turku, Turku, Finland.
  • Rebekka Lencer
    Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
  • Alessandro Bertolino
    Department of Basic Medical Sciences, Neuroscience and Sense Organs-University of Bari "Aldo Moro", Bari, Italy.
  • Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland.
  • Markus Noethen
    Institute of Human Genetics, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
  • Paolo Brambilla
    Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, TX, USA. Electronic address: paolo.brambilla1@unimi.it.
  • Stephen J Wood
    Orygen, National Centre of Excellence for Youth Mental Health, Melbourne, Australia.
  • Rachel Upthegrove
    Institute for Mental Health, University of Birmingham, Birmingham, UK.
  • Frauke Schultze-Lutter
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Anastasia Theodoridou
    Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Zurich, Switzerland.
  • Eva Meisenzahl
    Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University, Munich, Germany.