Deep Learning for Fully Automated Prediction of Overall Survival in Patients with Oropharyngeal Cancer Using FDG-PET Imaging.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published Date:

Abstract

PURPOSE: Accurate prognostic stratification of patients with oropharyngeal squamous cell carcinoma (OPSCC) is crucial. We developed an objective and robust deep learning-based fully-automated tool called the DeepPET-OPSCC biomarker for predicting overall survival (OS) in OPSCC using [F]fluorodeoxyglucose (FDG)-PET imaging.

Authors

  • Nai-Ming Cheng
    Department of Nuclear Medicine, Chang Gung Memorial Hospital, Keelung, and Chang Gung University, Taoyuan City, Taiwan, ROC.
  • Jiawen Yao
    PAII Inc., Bethesda, Maryland.
  • Jinzheng Cai
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
  • Xianghua Ye
    Department of Radiotherapy, The First Affiliated Hospital, Zhejiang University, Zhejiang, Hangzhou, China.
  • Shilin Zhao
    Departments of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Kui Zhao
    Department of PET Center, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
  • Wenlan Zhou
    NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • Isabella Nogues
  • Yuankai Huo
    Vanderbilt University, Nashville, TN 37212, USA.
  • Chun-Ta Liao
    Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Chang Gung University, Taoyuan, Taiwan.
  • Hung-Ming Wang
    Department of Medical Oncology, Chang Gung Memorial Hospital, Linkou, Chang Gung University, Taoyuan, Taiwan.
  • Chien-Yu Lin
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Chang Gung University, Taoyuan, Taiwan.
  • Li-Yu Lee
    Department of Pathology, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan City, Taiwan, ROC.
  • Jing Xiao
    Xiyuan Hospital, China Academy of Chinese Medical Sciences(CACMS), Beijing, China.
  • Le Lu
  • Ling Zhang
  • Tzu-Chen Yen
    Molecular Imaging Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.