The Role of GDF-15 in Heart Failure Patients With Chronic Kidney Disease.

Journal: The Canadian journal of cardiology
PMID: 30935637

Abstract

BACKGROUND: Growth differentiation factor-15 (GDF-15) is a stress-inducible cytokine and member of the transforming growth factor-β cytokine superfamily that refines prognostic assessment in subgroups of patients with heart failure (HF). We evaluated its role in HF patients with chronic kidney disease (CKD, estimated glomerular filtration rate <60 mL/min/1.73 m).

Authors

  • Jan Benes
    Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic.
  • Martin Kotrc
    Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic.
  • Peter Wohlfahrt
    Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic; Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.
  • Michael J Conrad
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Janka Franekova
    Department of Laboratory Methods, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic; Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Antonin Jabor
    Department of Laboratory Methods, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic; Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Petr Lupinek
    Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic.
  • Josef Kautzner
    Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic.
  • Vojtech Melenovsky
    Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic.
  • Petr Jarolim
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: pjarolim@bwh.harvard.edu.

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