Synthesis and characterization of Zinc oxide nanoparticles utilizing seed source of Ricinus communis and study of its antioxidant, antifungal and anticancer activity.

Journal: Materials science & engineering. C, Materials for biological applications
PMID: 30678976

Abstract

ZnO nanoparticles have been synthesized using solution combustion technique and its antioxidant, antifungal, anticancer activity was studied. Ricinus communis plant seed extract used as fuel in synthesis by the solution combustion technique. Powder X-ray diffraction (PXRD) demonstrates the arrangement of a crystalline hexagonal stage (ICDD card number 89-1397) with space aggregate P63mc (186) and cell parameters a = b = 3.253, c = 5.213 Å. The normal crystallite measure is 20 nm which is ascertained by Debye - Scherer's formula. The Purity of the sample and metal to oxygen bond development was affirmed by utilizing Fourier transformation infrared (FTIR) spectroscopy and the particle size and shape was confirmed by HRTEM. Antifungal action of ZnO NPs was studied against Aspergillus and Penicillium by well dispersion strategy. The antifungal activity shows that ZnO NPs constitute as an effective fungicidal agent against both Aspergillus (4 ± 0.5 mm) and Penicillium (3 mm ± 0.4 mm) at 30 μg/mL fixation. ZnO nanoparticles were subjected to antioxidant activity. The objective of the study was to analyze the anticancer property of ZnO NPs on MDA-MB 231 cancer cells. To check the efficacy of the synthesized drug ZnO NPs MTT assay was performed, that determines % viability and/or cytotoxicity. IC of ZnO NPs in case of MDA-MB-231 breast cancer was 7.103 μg/mL. Anticancer outcome demonstrates that ZnO NPs is active against in MDA-MB-231 cells.

Authors

  • N Shobha
    Department of Chemistry, Maharanis' Science College for Women, Bangalore, Karnataka, 560 001, India; Department Studies and Research in Chemistry, Tumkur University, Tumkur, Karnataka, 572 103, India; Department of Chemistry, BMS Engineering college, BMS Academy of Science and Research, Bull temple Road, Bangalore, 560 019, India. Electronic address: mahashobhasush@gmail.com.
  • N Nanda
    Department of Chemistry, BMS Engineering college, BMS Academy of Science and Research, Bull temple Road, Bangalore, 560 019, India; Department of Chemistry, BMS College for Women, Bangalore, Karnataka, 560 004, India.
  • Aladahalli Shivanna Giresha
    Department of Biochemistry, P.G-Centre, Mangalore University, Kodagu, Karnataka, 571 232, India.
  • Praveen Manjappa
    Department of Chemistry, MSRIT, Bangalore, Karnataka, 560 054, India.
  • Sophiya P
    Department of Biochemistry, P.G-Centre, Mangalore University, Kodagu, Karnataka, 571 232, India.
  • K K Dharmappa
    Department of Biochemistry, P.G-Centre, Mangalore University, Kodagu, Karnataka, 571 232, India.
  • B M Nagabhushana
    Department of Chemistry, MSRIT, Bangalore, Karnataka, 560 054, India.

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