A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome.

Journal: Nutrients
PMID: 29271886

Abstract

Since coffee may help to prevent the development of metabolic syndrome (MetS), we aimed to evaluate the short- and long-term effects of a coffee-based supplement on different features of diet-induced MetS. In this study, 24 Sprague Dawley rats were divided into control or nutraceuticals groups to receive a high-fat/high-fructose diet with or without a mixture of caffeic acid (30 mg/day), trigonelline (20 mg/day), and cafestol (1 mg/day) for 12 weeks. An additional 11 rats were assigned to an acute crossover study. In the chronic experiment, nutraceuticals did not alter body weight or glycemic control, but improved fed hyperinsulinemia (mean difference = 30.80 mU/L, = 0.044) and homeostatic model assessment-insulin resistance (HOMA-IR) (mean difference = 15.29, = 0.033), and plasma adiponectin levels (mean difference = -0.99 µg/mL, = 0.048). The impact of nutraceuticals on post-prandial glycemia tended to be more pronounced after acute administration than at the end of the chronic study. Circulating (mean difference = 4.75 U/L, = 0.014) and intrahepatocellular alanine transaminase activity was assessed by hyperpolarized-C nuclear magnetic resonance NMR spectroscopy and found to be reduced by coffee nutraceuticals at endpoint. There was also a tendency towards lower liver triglyceride content and histological steatosis score in the intervention group. In conclusion, a mixture of coffee nutraceuticals improved insulin sensitivity and exhibited hepatoprotective effects in a rat model of MetS. Higher dosages with or without caffeine deserve to be studied in the future.

Authors

  • Pedram Shokouh
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark. Shokouh.P@gmail.com.
  • Per Bendix Jeppesen
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark. per.bendix.jeppesen@clin.au.dk.
  • Kjeld Hermansen
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark. kjeld.hermansen@aarhus.rm.dk.
  • Natalja P Nørskov
    Department of Animal Science, Aarhus University, 8830 Tjele, Denmark. natalja.norskov@anis.au.dk.
  • Christoffer Laustsen
    Department of Clinical Medicine, MR Research Centre, Aarhus University, Aarhus, Denmark.
  • Stephen Jacques Hamilton-Dutoit
    Institute of Pathology, Aarhus University Hospital Skejby, 8200 Aarhus N, Denmark. stephami@rm.dk.
  • Haiyun Qi
    Department of Clinical Medicine, MR Research Centre, Aarhus University, Aarhus, Denmark.
  • Hans Stødkilde-Jørgensen
    MR Research Centre, Aarhus University Hospital Skejby, 8200 Aarhus N, Denmark. hsj@clin.au.dk.
  • Søren Gregersen
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, Denmark. soeren.gregersen@aarhus.rm.dk.

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