Machine learning-based discovery of UPP1 as a key oncogene in tumorigenesis and immune escape in gliomas.

Journal: Frontiers in immunology
PMID: 39380997

Abstract

INTRODUCTION: Gliomas are the most common and aggressive type of primary brain tumor, with a poor prognosis despite current treatment approaches. Understanding the molecular mechanisms underlying glioma development and progression is critical for improving therapies and patient outcomes.

Authors

  • Zigui Chen
    Department of Neurosurgery, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, China.
  • Chao Liu
    Anti-Drug Technology Center of Guangdong Province, National Anti-Drug Laboratory Guangdong Regional Center, Guangzhou 510230, China.
  • Chunyuan Zhang
  • Ying Xia
    Australian e-Health Research Centre, CSIRO, Brisbane, QLD, 4029, Australia.
  • Jun Peng
    a Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
  • Changfeng Miao
    Department of Neurosurgery Second Branche, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
  • Qisheng Luo
    Department of Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.

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