Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

Journal: The lancet. Gastroenterology & hepatology
PMID: 28404110

Abstract

BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitutes about 20% of HCV infections worldwide, the prevalence in Egypt is more than 90%. We assessed the efficacy and safety of the two direct-acting antiviral drugs ombitasvir, an NS5A inhibitor, and paritaprevir, an NS3/4A protease inhibitor dosed with ritonavir, plus ribavirin in treatment of chronic HCV infection in Egypt.

Authors

  • Imam Waked
    National Liver Institute, Menoufiya, Egypt. Electronic address: iwaked@liver-eg.org.
  • Gamal Shiha
    Egyptian Liver Research Institute And Hospital (ELRIAH), Dakahliah, Egypt.
  • Roula B Qaqish
    AbbVie Incorporated, North Chicago, IL, USA.
  • Gamal Esmat
    Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Ayman Yosry
    Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Mohamed Hassany
    Tropical Medicine Department, National Hepatology & Tropical Medicine Research Institute (NHTMRI), Cairo, Egypt.
  • Reham Soliman
    Egyptian Liver Research Institute And Hospital (ELRIAH), Mansoura, Egypt.
  • Mohammad A Mohey
    Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Naglaa Allam
    National Liver Institute, Menoufiya, Egypt.
  • Naglaa Zayed
    Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Tarik Asselah
    Service d'Hépatologie, AP-HP Hôpital Beaujon, Clichy, Centre de Recherche sur l'Inflammation (CRI), UMR 1149 Inserm, Université Paris Diderot, Paris, France.
  • Coleen Hall
    AbbVie Incorporated, North Chicago, IL, USA.
  • Rebecca Redman
    AbbVie Incorporated, North Chicago, IL, USA.
  • Niloufar Mobashery
    AbbVie Incorporated, North Chicago, IL, USA.
  • Wahid Doss
    National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.

Keywords

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