AIMC Topic: Sustained Virologic Response

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AI-Safe-C score: Assessing liver-related event risks in patients without cirrhosis after successful direct-acting antiviral treatment.

Journal of hepatology Sep 20, 2024
BACKGROUND & AIMS: Direct-acting antivirals (DAAs) have considerably improved chronic hepatitis C (HCV) treatment; however, follow-up after sustained virological response (SVR) typically neglects the risk of liver-related events (LREs). This study in...
Adult Male Middle Aged Risk Assessment Republic of Korea Female Risk Factors Aged Hepatitis C, Chronic France Hong Kong Sustained Virologic Response ROC Curve Liver Neoplasms Antiviral Agents Liver Cirrhosis Humans Artificial Intelligence
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Assessment of a Deep Learning Model to Predict Hepatocellular Carcinoma in Patients With Hepatitis C Cirrhosis.

JAMA network open Sep 1, 2020
IMPORTANCE: Deep learning, a family of machine learning models that use artificial neural networks, has achieved great success at predicting outcomes in nonmedical domains.
Humans Neural Networks, Computer Prognosis Electronic Health Records Deep Learning Liver Cirrhosis Incidence Area Under Curve Liver Neoplasms Hepatitis C, Chronic Carcinoma, Hepatocellular Sustained Virologic Response Female Male Veterans Health Services Middle Aged Chronic Disease Indicators Risk Assessment
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Ritonavir-boosted paritaprevir, ombitasvir plus ribavirin could improve eGFR in patients with renal impairment and HCV: an Egyptian cohort.

Expert review of gastroenterology & hepatology Nov 13, 2018
BACKGROUND: The present study aimed at evaluation of changes in estimated glomerular filtration rate (eGFR) among chronic Hepatitis C virus (HCV) patients with chronic kidney disease (CKD) Stages 3-5 who were treated with 12 weeks of ritonavir-booste...
Sustained Virologic Response Egypt Sulfonamides Hepacivirus Proline Carbamates Treatment Outcome Middle Aged Drug Therapy, Combination Glomerular Filtration Rate Lactams, Macrocyclic Hepatitis C, Chronic Renal Dialysis Macrocyclic Compounds Cyclopropanes Valine Viral Load Ribavirin Recovery of Function Anilides Time Factors Humans Prospective Studies Female Aged Antiviral Agents Young Adult Adult Male Genotype Kidney Renal Insufficiency, Chronic
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Valine Middle Aged Aged, 80 and over Liver Cirrhosis Adolescent Proline Drug Administration Schedule Humans Young Adult Treatment Outcome Antiviral Agents Ritonavir Female Adult Anilides Follow-Up Studies Genotype Drug Therapy, Combination Aged Male Carbamates Cyclopropanes Egypt Hepatitis C, Chronic Lactams, Macrocyclic Sulfonamides Macrocyclic Compounds Hepacivirus Ribavirin Administration, Oral Sustained Virologic Response
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clin...
Valine Drug Administration Schedule Anilides Carbamates Proline Ritonavir Drug Therapy, Combination Hepatitis C, Chronic Lactams, Macrocyclic Macrocyclic Compounds Ribavirin Sustained Virologic Response Adolescent Antiviral Agents Genotype Treatment Outcome Follow-Up Studies Cyclopropanes Sulfonamides Hepacivirus Young Adult Adult Male Middle Aged Humans Female Aged Aged, 80 and over
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