A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear.

Journal: The American journal of sports medicine
PMID: 28146402

Abstract

BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression from anterior cruciate ligament (ACL) injury to PTOA is multifactorial, involving the interplay between biomechanical disturbances and biochemical homeostasis of articular cartilage.

Authors

  • Christian Lattermann
    Department of Orthopedic Surgery and Sports Medicine, University of Kentucky, Lexington, Kentucky, USA.
  • Cale A Jacobs
    Department of Orthopedic Surgery and Sports Medicine, University of Kentucky, Lexington, Kentucky, USA.
  • Mary Proffitt Bunnell
    Division of Physical Therapy, University of Kentucky, Lexington, Kentucky, USA.
  • Laura J Huston
    Vanderbilt Orthopaedic Institute, Nashville, Tennessee, USA.
  • Lee G Gammon
    University of Kentucky College of Medicine, Lexington, Kentucky, USA.
  • Darren L Johnson
    Department of Orthopedic Surgery and Sports Medicine, University of Kentucky, Lexington, Kentucky, USA.
  • Emily K Reinke
    Vanderbilt Orthopaedic Institute, Nashville, Tennessee, USA.
  • Janet L Huebner
    Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.
  • Virginia B Kraus
    Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.
  • Kurt P Spindler
    Cleveland Clinic Sports Health Center, Garfield Heights, Ohio, USA.

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