AI Medical Compendium Journal:
Biochemical and biophysical research communications

Showing 21 to 23 of 23 articles

Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Cells, Cultured Macrophages Animals Mice Signal Transduction RANK Ligand Mice, Inbred C57BL Dose-Response Relationship, Drug NF-kappa B Osteogenesis RAW 264.7 Cells Osteoblasts Glycosides
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Supervised machine learning techniques to predict binding affinity. A study for cyclin-dependent kinase 2.

Biochemical and biophysical research communications Oct 7, 2017
Here we report the development of a machine-learning model to predict binding affinity based on the crystallographic structures of protein-ligand complexes. We used an ensemble of crystallographic structures (resolution better than 1.5 Å resolution) ...
Humans Molecular Docking Simulation Drug Design Antineoplastic Agents ROC Curve Databases, Protein Supervised Machine Learning Ligands Inhibitory Concentration 50 Datasets as Topic Protein Kinase Inhibitors Thermodynamics Cyclin-Dependent Kinase 2
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Molecular surfaces modeling: Advancements in deep learning for molecular interactions and predictions.

Biochemical and biophysical research communications May 12, 2025
Molecular surface analysis can provide a high-dimensional, rich representation of molecular properties and interactions, which is crucial for enabling powerful predictive modeling and rational molecular design across diverse scientific and technologi...
Humans Artificial Intelligence Algorithms Deep Learning Proteins Models, Molecular Surface Properties
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