AIMC Topic: Glycosides

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Integrating mass defect filtering and targeted molecular networking for foodomics research: A case study of Magnolia officinalis cortex.

Food research international (Ottawa, Ont.) Apr 18, 2025
Mass spectrometry (MS)-based foodomics is widely used to tackle complex challenges in food science, although its effectiveness is often hampered by extensive data redundancy. To address this limitation, a novel MS-based foodomics strategy, integratin...
Support Vector Machine Mass Spectrometry Glycosides Lignans Magnolia Food Analysis Alkaloids
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Single-Molecule Identification and Quantification of Steviol Glycosides with a Deep Learning-Powered Nanopore Sensor.

ACS nano Aug 27, 2024
Steviol glycosides (SGs) are a class of high-potency noncalorie natural sweeteners made up of a common diterpenoid core and varying glycans. Thus, the diversity of glycans in composition, linkage, and isomerism results in the tremendous structural co...
Nanopores Diterpenes, Kaurane Glycosides Deep Learning Glucosides
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Molecular Networking and On-Tissue Chemical Derivatization for Enhanced Identification and Visualization of Steroid Glycosides by MALDI Mass Spectrometry Imaging.

Analytical chemistry Nov 8, 2022
Spatial metabolomics describes the spatially resolved analysis of interconnected pathways, biochemical reactions, and transport processes of small molecules in the spatial context of tissues and cells. However, a broad range of metabolite classes (e....
Plants Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Glycosides Metabolomics Artificial Intelligence Metabolome
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Metabonomic and transcriptomic analyses of glycosides tablet-induced hepatotoxicity in rats.

Drug and chemical toxicology May 23, 2022
We aimed to explore novel biomarkers involved in alterations of metabolism and gene expression related to the hepatotoxic effects of glycosides tablet (TGT) in rats. Rats were randomly divided into groups based on oral administration of TGTs for 6 w...
Chemical and Drug Induced Liver Injury Tripterygium Tablets Glycosides Liver Drugs, Chinese Herbal Biomarkers Transcriptome Rats Animals
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Plant-Based Beverages as Good Sources of Free and Glycosidic Plant Sterols.

Nutrients Dec 29, 2017
To address the ever-growing group of health-conscious consumers, more and more nutritional and health claims are being used on food products. Nevertheless, only very few food constituents, including plant sterols, have been appointed an approved heal...
Fruit and Vegetable Juices Phytosterols Glycosides Plant Extracts Tandem Mass Spectrometry Chromatography, High Pressure Liquid Nutritive Value
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Identification and characterization of the structure-activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum.

Scientific reports Dec 20, 2017
The adverse effects of Polygonum (P.) multiflorum, including abnormal bilirubin metabolism, are a serious public health issue. As uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme responsible for bilirubin metabolism, ...
Glucuronosyltransferase Anthraquinones Glycosides Plant Extracts Chromatography, High Pressure Liquid Male Fallopia multiflora Rats Microsomes, Liver In Vitro Techniques Structure-Activity Relationship Rats, Sprague-Dawley Plant Roots Animals
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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Glycosides Signal Transduction RANK Ligand Mice, Inbred C57BL Cells, Cultured Animals Osteogenesis Dose-Response Relationship, Drug RAW 264.7 Cells Mice Macrophages Osteoblasts NF-kappa B
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Optimization of extraction of linarin from Flos chrysanthemi indici by response surface methodology and artificial neural network.

Journal of separation science Apr 24, 2017
The extraction of linarin from Flos chrysanthemi indici by ethanol was investigated. Two modeling techniques, response surface methodology and artificial neural network, were adopted to optimize the process parameters, such as, ethanol concentration,...
Neural Networks, Computer Flowers Glycosides Chrysanthemum
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Support vector regression-guided unravelling: antioxidant capacity and quantitative structure-activity relationship predict reduction and promotion effects of flavonoids on acrylamide formation.

Scientific reports Sep 2, 2016
We used the support vector regression (SVR) approach to predict and unravel reduction/promotion effect of characteristic flavonoids on the acrylamide formation under a low-moisture Maillard reaction system. Results demonstrated the reduction/promotio...
Quantitative Structure-Activity Relationship Acrylamide Maillard Reaction Oxidation-Reduction Linear Models Hydroxyl Radical Glycosides Support Vector Machine Flavonoids Antioxidants
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