Biochemical and biophysical research communications
Nov 11, 2025
Osteoarthritis (OA) is the most common degenerative joint disease, and the complexity of its molecular mechanisms has hindered the development of effective diagnostic and therapeutic strategies. In this study, we integrated five independent OA RNA-se...
Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), results from immune abnormalities. Qingre Kasen granules (QS), which have chicory as the main ingredient, play a significant role in treating various inflammator...
BACKGROUND: Ovarian cancer (OC) poses a significant public health challenge due to its dismal prognosis and low survival rates. However, the mechanism of OC development remains unclear.
BACKGROUND: Chronic allergic rhinitis and asthma syndrome (CARAS) is a comorbid inflammatory condition affecting both upper and lower airways, with limited treatment options. Artesunate (ART), a derivative of artemisinin, has shown anti-inflammatory ...
Environmental stress contributes to the development of depression through neuro-immune interactions, yet the underlying molecular mechanisms and associated clinical diagnostic biomarkers remain unclear. We established a psychosocial stress mouse mode...
Cryptorchidism, a common male reproductive disorder characterized by undescended testes, is associated with infertility and increased cancer risk. While its etiology remains incompletely understood, accumulating evidence suggests that immune-inflamma...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Apr 10, 2025
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant health concern worldwide, exhibiting an increasing incidence that necessitates immediate intervention. Epigallocatechin-3-gallate (EGCG) has shown significant pharmaco...
Breast cancer, the second most prevalent cancer among women worldwide, necessitates the exploration of novel therapeutic approaches. To target the four subgroups of breast cancer "hormone receptor-positive and HER2-negative, hormone receptor-positive...
BACKGROUND: Abdominal aortic aneurysm (AAA) poses a significant health risk and is influenced by various compositional features. This study aimed to develop an artificial intelligence-driven multiomics predictive model for AAA subtypes to identify he...
We introduce a computational approach for the design of target-specific peptides. Our method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta FlexPepDock for peptide sequence generation and binding affinity assessment. Sub...
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