Journal of bioinformatics and computational biology
Sep 23, 2023
The evolution of single-cell technology is ongoing, continually generating massive amounts of data that reveal many mysteries surrounding intricate diseases. However, their drawbacks continue to constrain us. Among these, annotating cell types in sin...
Journal of bioinformatics and computational biology
Aug 24, 2023
Metabolic pathways play a crucial role in understanding the biochemistry of organisms. In metabolic pathways, modules refer to clusters of interconnected reactions or sub-networks representing specific functional units or biological processes within ...
Journal of bioinformatics and computational biology
Jun 22, 2023
Drug synergy has emerged as a viable treatment option for malignancy. Drug synergy reduces toxicity, improves therapeutic efficacy, and overcomes drug resistance when compared to single-drug doses. Thus, it has attained significant interest from acad...
Journal of bioinformatics and computational biology
Mar 11, 2023
Nucleus segmentation represents the initial step for histopathological image analysis pipelines, and it remains a challenge in many quantitative analysis methods in terms of accuracy and speed. Recently, deep learning nucleus segmentation methods hav...
Journal of bioinformatics and computational biology
Mar 9, 2023
Protein secondary structure prediction (PSSP) is an important and challenging task in protein bioinformatics. Protein secondary structures (SSs) are categorized in regular and irregular structure classes. Regular SSs, representing nearly 50% of amino...
Journal of bioinformatics and computational biology
Mar 8, 2023
To solve the problem of the lack of representativeness of the training set and the poor prediction accuracy due to the limited number of training samples when the machine learning method is used for the classification and prediction of pharmacokineti...
Journal of bioinformatics and computational biology
Feb 10, 2023
This work proposes a machine learning-based phylogenetic tree generation model based on agglomerative clustering (PTGAC) that compares protein sequences considering all known chemical properties of amino acids. The proposed model can serve as a suita...
Journal of bioinformatics and computational biology
Dec 14, 2022
In this study, we propose , a system that aims to computationally generate novel antiviral peptides (AVPs). This system relies on the key premise of the Generative Adversarial Network (GAN) model and the Feedback method. GAN, a generative modeling ap...
Journal of bioinformatics and computational biology
Aug 3, 2022
RNA 5-hydroxymethylcytosine (5 hmC) is an important RNA modification, which plays vital role in several biological processes. Currently, it is a hot topic to identify 5 hmC sites due to its benefit in understanding its biological functions. Therefore...
Journal of bioinformatics and computational biology
Jul 25, 2022
The basic helix loop helix (bHLH) superfamily is a large and diverse protein family that plays a role in various vital functions in nearly all animals and plants. The bHLH proteins form one of the largest families of transcription factors found in pl...