Protein science : a publication of the Protein Society
Aug 26, 2021
In contrast to artificial intelligence and machine learning approaches, KEGG (https://www.kegg.jp) has relied on human intelligence to develop "models" of biological systems, especially in the form of KEGG pathway maps that are manually created by ca...
Protein science : a publication of the Protein Society
Jun 28, 2021
Enzymes are critical proteins in every organism. They speed up essential chemical reactions, help fight diseases, and have a wide use in the pharmaceutical and manufacturing industries. Wet lab experiments to figure out an enzyme's function are time ...
Protein science : a publication of the Protein Society
Mar 25, 2021
EDock-ML is a web server that facilitates the use of ensemble docking with machine learning to help decide whether a compound is worthwhile to be considered further in a drug discovery process. Ensemble docking provides an economical way to account f...
Protein science : a publication of the Protein Society
Nov 20, 2020
For decades, biologists have relied on software to visualize and interpret imaging data. As techniques for acquiring images increase in complexity, resulting in larger multidimensional datasets, imaging software must adapt. ImageJ is an open-source i...
Protein science : a publication of the Protein Society
Aug 9, 2016
Predicting protein-protein interactions (PPIs) is a challenging task and essential to construct the protein interaction networks, which is important for facilitating our understanding of the mechanisms of biological systems. Although a number of high...
Protein science : a publication of the Protein Society
Jun 1, 2025
Accurate identification of angiotensin-I-converting enzyme (ACE) inhibitory peptides is essential for understanding the primary factor regulating the renin-angiotensin system and guiding the development of new drug candidates. Given the inherent chal...
Protein science : a publication of the Protein Society
May 1, 2025
Deep learning methods have played an increasingly pivotal role in advancing side-chain packing and mutation effect prediction (ΔΔG) for protein complexes. Although these two tasks are inherently closely related, they are typically treated separately ...
Protein science : a publication of the Protein Society
Feb 1, 2025
Proteins' flexibility is a feature in communicating changes in cell signaling instigated by binding with secondary messengers, such as calcium ions, associated with the coordination of muscle contraction, neurotransmitter release, and gene expression...
Protein science : a publication of the Protein Society
Feb 1, 2025
Protein structure holds immense potential for pathogenicity prediction, albeit structure-based predictors are limited compared to the sequence-based counterparts due to the "structure knowledge gap" between large number of available protein sequences...
Protein science : a publication of the Protein Society
Feb 1, 2025
Protein aggregation is critical to various biological and pathological processes. Besides, it is also an important property in biotherapeutic development. However, experimental methods to profile protein aggregation are costly and labor-intensive, dr...