AIMC Topic: Peptidyl-Dipeptidase A

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Machine learning discovery of novel antihypertensive peptides from highland barley protein inhibiting angiotensin I-converting enzyme (ACE).

Food research international (Ottawa, Ont.) Jan 6, 2025
Hypertension is a major global health concern, and there is a need for new antihypertensive agents derived from natural sources. This study aims to identify novel angiotensin I-converting enzyme (ACE) inhibitors from bioactive peptides derived from f...
Humans Machine Learning Peptides Plant Proteins Angiotensin-Converting Enzyme Inhibitors Hordeum Peptidyl-Dipeptidase A Molecular Docking Simulation Antihypertensive Agents Molecular Dynamics Simulation
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Deepstack-ACE: A deep stacking-based ensemble learning framework for the accelerated discovery of ACE inhibitory peptides.

Methods (San Diego, Calif.) Dec 19, 2024
Identifying angiotensin-I-converting enzyme (ACE) inhibitory peptides accurately is crucial for understanding the primary factor that regulates the renin-angiotensin system and for providing guidance in developing new potential drugs. Given the inher...
Ensemble Learning Deep Learning Angiotensin-Converting Enzyme Inhibitors Peptidyl-Dipeptidase A Humans Neural Networks, Computer Peptides Drug Discovery
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Exogenous Chemicals Impact Virus Receptor Gene Transcription: Insights from Deep Learning.

Environmental science & technology May 15, 2023
Despite the fact that coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been disrupting human life and health worldwide since the outbreak in late 2019, the impact of exogenous substance ...
Peptidyl-Dipeptidase A Transcription, Genetic Receptors, Virus COVID-19 SARS-CoV-2 Deep Learning Angiotensin-Converting Enzyme 2 Humans
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Artificial Intelligence-Assisted Meta-Analysis of the Frequency of ACE I/D Polymorphisms in Centenarians and Other Long-Lived Individuals.

International journal of molecular sciences Feb 8, 2023
Current research on the angiotensin-converting-enzyme () gene has yielded controversial results on whether different polymorphisms are linked with human longevity. polymorphisms are a risk factor for Alzheimer's disease and age-onset diseases that ...
Artificial Intelligence Aged, 80 and over Genotype Polymorphism, Genetic Humans Peptidyl-Dipeptidase A Centenarians
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A heuristic, computer-driven and top-down approach to identify novel bioactive peptides: A proof-of-principle on angiotensin I converting enzyme inhibitory peptides.

Food research international (Ottawa, Ont.) Oct 13, 2021
Bioactive peptides are short peptides (3-20 amino acid residues in length) endowed of specific biological activities. The identification and characterization of bioactive peptides of food origin are crucial to better understand the physiological cons...
Computers Peptides Dietary Supplements Peptidyl-Dipeptidase A Computer Heuristics
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Toward a Coronavirus Knowledge Graph.

Genes Jun 29, 2021
This study builds a coronavirus knowledge graph (KG) by merging two information sources. The first source is Analytical Graph (AG), which integrates more than 20 different public datasets related to drug discovery. The second source is CORD-19, a col...
STAT1 Transcription Factor Chloroquine Hydroxychloroquine Receptors, Interleukin-6 SARS-CoV-2 PubMed Knowledge Bases Pattern Recognition, Automated Peptidyl-Dipeptidase A Computer Graphics Hemorrhagic Fever, Ebola Humans COVID-19 Databases, Factual
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Predictive Modeling of Angiotensin I-Converting Enzyme Inhibitory Peptides Using Various Machine Learning Approaches.

Journal of agricultural and food chemistry Oct 1, 2020
Food-derived angiotensin I-converting enzyme (ACE) inhibitory peptides could potentially be used as safe supportive therapeutic products for high blood pressure. Theoretical approaches are promising methods with the advantage through exploring the re...
Peptidyl-Dipeptidase A Models, Molecular Angiotensin-Converting Enzyme Inhibitors Hydrogen Bonding Machine Learning Peptides Molecular Docking Simulation
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Decreased circulating catestatin levels are associated with coronary artery disease: The emerging anti-inflammatory role.

Atherosclerosis Dec 24, 2018
BACKGROUND AND AIMS: The neuropeptide catestatin (CST) is an endogenous nicotinic cholinergic antagonist that acts as pleiotropic cardiac protective hormone. This study investigated the association between CST and coronary artery disease (CAD) and th...
Angiotensin-Converting Enzyme 2 Chromogranin A Mice, Knockout, ApoE Peptidyl-Dipeptidase A Atherosclerosis Down-Regulation Cell Adhesion Molecules Severity of Illness Index Human Umbilical Vein Endothelial Cells Biomarkers Plaque, Atherosclerotic Humans Case-Control Studies Female Peptide Fragments Cells, Cultured Disease Models, Animal Animals Cytokines Anti-Inflammatory Agents Male Coronary Artery Disease
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Angiotensin Converting Enzyme Inhibitory and Antioxidant Activities of Enzymatic Hydrolysates of Korean Native Cattle (Hanwoo) Myofibrillar Protein.

BioMed research international Dec 17, 2017
The purpose of this study was to determine the angiotensin converting enzyme (ACE) inhibitory and antioxidant activities of myofibrillar protein hydrolysates (HMPHs) of different molecular weights (<3 and <10 kDa) derived from Korean native cattle (H...
Protein Hydrolysates Peptidyl-Dipeptidase A Myofibrils Cattle Antioxidants Animals Hydrolysis Peptides Free Radical Scavengers
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In silico identification of milk antihypertensive di- and tripeptides involved in angiotensin I-converting enzyme inhibitory activity.

Nutrition research (New York, N.Y.) Jul 28, 2017
Identification of bioactive milk peptides could improve food technology through improved selection of food supplements with a focus on antihypertensive properties. We hypothesized that angiotensin I-converting enzyme (ACE) inhibitory activities of mi...
Computational Biology Dietary Supplements Antihypertensive Agents Models, Molecular Peptide Fragments Dipeptides Hydrophobic and Hydrophilic Interactions Humans Peptidyl-Dipeptidase A Animals Molecular Docking Simulation Proteolysis Cattle Binding Sites Milk Proteins Angiotensin-Converting Enzyme Inhibitors Expert Systems Quantitative Structure-Activity Relationship Catalytic Domain Protein Conformation Oligopeptides Hydrogen Bonding
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