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Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction.

BMC bioinformatics 33183223
BACKGROUND: Protein kinases are a large family of druggable proteins that are genomically and proteomically altered in many human cancers. Kinase-targeted drugs are emerging as promising avenues for personalized medicine because of the differential r...
Afatinib Carcinoma, Non-Small-Cell Lung Cell Line, Tumor ErbB Receptors Humans Lapatinib Lung Neoplasms MAP Kinase Signaling System Mutation Neural Networks, Computer Precision Medicine Protein Interaction Maps Protein Kinase Inhibitors Quantitative Structure-Activity Relationship
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