AIMC Topic: Lapatinib

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Noncirrhotic Portal Hypertension after Trastuzumab Emtansine in HER2-positive Breast Cancer as Determined by Deep Learning-measured Spleen Volume at CT.

Radiology Aug 9, 2022
Background Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for use in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Case reports have suggested an association between T-DM1 and portal hypertension. Purpo...
Humans Retrospective Studies Tomography, X-Ray Computed Female Breast Neoplasms Middle Aged Deep Learning Antineoplastic Combined Chemotherapy Protocols Capecitabine Receptor, ErbB-2 Spleen Lapatinib Hypertension, Portal Splenomegaly Ado-Trastuzumab Emtansine
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Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction.

BMC bioinformatics Nov 12, 2020
BACKGROUND: Protein kinases are a large family of druggable proteins that are genomically and proteomically altered in many human cancers. Kinase-targeted drugs are emerging as promising avenues for personalized medicine because of the differential r...
Humans Neural Networks, Computer Precision Medicine Cell Line, Tumor Protein Interaction Maps Lung Neoplasms Carcinoma, Non-Small-Cell Lung Mutation MAP Kinase Signaling System Quantitative Structure-Activity Relationship ErbB Receptors Protein Kinase Inhibitors Lapatinib Afatinib
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Disentangling multidimensional spatio-temporal data into their common and aberrant responses.

PloS one Apr 22, 2015
With the advent of high-throughput measurement techniques, scientists and engineers are starting to grapple with massive data sets and encountering challenges with how to organize, process and extract information into meaningful structures. Multidime...
Humans Neural Networks, Computer Algorithms Female Breast Neoplasms Biomarkers, Tumor Gene Regulatory Networks Gene Expression Regulation, Neoplastic Principal Component Analysis Mutation Proto-Oncogene Proteins c-akt Protein Array Analysis Quinazolines Lapatinib
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