MOTIVATION: An important step in structure-based drug design consists in the prediction of druggable binding sites. Several algorithms for detecting binding cavities, those likely to bind to a small drug compound, have been developed over the years b...
MOTIVATION: 5-Methylcytosine and 5-Hydroxymethylcytosine in DNA are major epigenetic modifications known to significantly alter mammalian gene expression. High-throughput assays to detect these modifications are expensive, labor-intensive, unfeasible...
Health insurers may attempt to design their health plans to attract profitable enrollees while deterring unprofitable ones. Such insurers would not be delivering socially efficient levels of care by providing health plans that maximize societal benef...
When searching real-world scenes, human attention is guided by knowledge of the plausible size of target object (if an object is six feet tall, it isn't your cat). Computer algorithms typically do not do this, but perhaps they should.
Two critical challenges in the design and synthesis of molecular robots are modularity and algorithm simplicity. We demonstrate three modular building blocks for a DNA robot that performs cargo sorting at the molecular level. A simple algorithm encod...
The Journal of the Acoustical Society of America
Sep 1, 2017
Ground parrot vocalisation can be considered as an audio event. Test-based diverse density multiple instance learning (TB-DD-MIL) is proposed for detecting this event in audio files recorded in the field. The proposed method is motivated by the advan...
The Journal of the Acoustical Society of America
Sep 1, 2017
The modulation filtering approach to robust automatic speech recognition (ASR) is based on enhancing perceptually relevant regions of the modulation spectrum while suppressing the regions susceptible to noise. In this paper, a data-driven unsupervise...
Machine learning algorithms increasingly influence our decisions and interact with us in all parts of our daily lives. Therefore, just as we consider the safety of power plants, highways, and a variety of other engineered socio-technical systems, we ...
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