AIMC Topic: Alkylating Agents
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A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications.
BMC bioinformatics
Mar 2, 2021
BACKGROUND: Non-targeted cytotoxics with anticancer activity are often developed through preclinical stages using response criteria observed in cell lines and xenografts. A panel of the NCI-60 cell lines is frequently the first line to define tumor t...
Metabonomics of d-glucaro-1,4-lactone in preventing diethylnitrosamine-induced liver cancer in rats.
Pharmaceutical biology
Dec 1, 2018
CONTEXT: d-Glucaro-1,4-lactone (1,4-GL) exists in many vegetables and fruits. Metabonomics has not been used to investigate the role of 1,4-GL in preventing liver cancer.
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