AIMC Topic: Androgen Receptor Antagonists

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A machine learning model (Sol_ME) assisted development of a unit-dose lipid formulation for apalutamide: formulation, pharmacokinetics, and pharmacodynamics evaluation.

International journal of pharmaceutics Aug 24, 2025
PURPOSE: The development of a novel lipid-based formulation for apalutamide, a potent androgen receptor inhibitor for non-metastatic castration-resistant prostate cancer (nmCRPC), is explored in this study.
Capsules Prostatic Neoplasms, Castration-Resistant Male Androgen Receptor Antagonists Machine Learning Cell Line, Tumor Thiohydantoins Biological Availability Chemistry, Pharmaceutical Animals Drug Compounding Lipids Humans Excipients Solubility
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Drug-like molecules targeting androgen receptor's allosteric binding sites selected by augmented AI and high-throughput screening as antitumor agents against prostate cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Aug 2, 2025
Despite therapeutic advancements, metastatic and nonmetastatic castration-resistant prostate cancer (mCRPC and nmCRPC) remain incurable due to drug resistance, partly due to Androgen receptor (AR) gene abnormalities and splice variants. An Augmented ...
Prostatic Neoplasms Molecular Dynamics Simulation Cell Proliferation Drug Screening Assays, Antitumor Receptors, Androgen Allosteric Site High-Throughput Screening Assays Prostatic Neoplasms, Castration-Resistant Male Molecular Docking Simulation Antineoplastic Agents Cell Line, Tumor Humans Artificial Intelligence Androgen Receptor Antagonists
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AndroPred: an artificial intelligence-based model for predicting androgen receptor inhibitors.

Journal of biomolecular structure & dynamics Jul 26, 2023
Androgen receptor (AR), a steroid receptor, plays a pivotal role in the pathogenesis of prostate cancer (PCa). AR controls the transcription of genes that help cells avoid apoptosis and proliferate, thereby contributing to the development of PCa. Und...
Androgen Receptor Antagonists Humans Artificial Intelligence Models, Molecular Receptors, Androgen Male Prostatic Neoplasms Quantitative Structure-Activity Relationship Drug Discovery Machine Learning Algorithms
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Deep Learning Modeling of Androgen Receptor Responses to Prostate Cancer Therapies.

International journal of molecular sciences Aug 14, 2020
Gain-of-function mutations in human androgen receptor (AR) are among the major causes of drug resistance in prostate cancer (PCa). Identifying mutations that cause resistant phenotype is of critical importance for guiding treatment protocols, as well...
Transcription, Genetic Androgen Receptor Antagonists Mutation Receptors, Androgen ROC Curve Humans Prostatic Neoplasms Deep Learning Cell Line, Tumor Neural Networks, Computer Male
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Machine Learning Consensus To Predict the Binding to the Androgen Receptor within the CoMPARA Project.

Journal of chemical information and modeling Feb 11, 2019
The nuclear androgen receptor (AR) is one of the most relevant biological targets of Endocrine Disrupting Chemicals (EDCs), which produce adverse effects by interfering with hormonal regulation and endocrine system functioning. This paper describes n...
Androgen Receptor Antagonists Molecular Docking Simulation Drug Discovery Endocrine Disruptors Machine Learning Humans Androgens Protein Binding Software Receptors, Androgen
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