AIMC Topic: Androgen Receptor Antagonists

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AndroPred: an artificial intelligence-based model for predicting androgen receptor inhibitors.

Journal of biomolecular structure & dynamics Jul 26, 2023
Androgen receptor (AR), a steroid receptor, plays a pivotal role in the pathogenesis of prostate cancer (PCa). AR controls the transcription of genes that help cells avoid apoptosis and proliferate, thereby contributing to the development of PCa. Und...
Humans Artificial Intelligence Machine Learning Algorithms Male Drug Discovery Models, Molecular Prostatic Neoplasms Receptors, Androgen Quantitative Structure-Activity Relationship Androgen Receptor Antagonists
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Deep Learning Modeling of Androgen Receptor Responses to Prostate Cancer Therapies.

International journal of molecular sciences Aug 14, 2020
Gain-of-function mutations in human androgen receptor (AR) are among the major causes of drug resistance in prostate cancer (PCa). Identifying mutations that cause resistant phenotype is of critical importance for guiding treatment protocols, as well...
Humans Neural Networks, Computer Male Deep Learning Cell Line, Tumor ROC Curve Prostatic Neoplasms Mutation Receptors, Androgen Transcription, Genetic Androgen Receptor Antagonists
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Machine Learning Consensus To Predict the Binding to the Androgen Receptor within the CoMPARA Project.

Journal of chemical information and modeling Feb 11, 2019
The nuclear androgen receptor (AR) is one of the most relevant biological targets of Endocrine Disrupting Chemicals (EDCs), which produce adverse effects by interfering with hormonal regulation and endocrine system functioning. This paper describes n...
Humans Machine Learning Software Molecular Docking Simulation Drug Discovery Protein Binding Receptors, Androgen Endocrine Disruptors Androgens Androgen Receptor Antagonists
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