AIMC Topic: Biological Ontologies

Clear Filters Showing 271 to 280 of 645 articles

Using semantics for representing experimental protocols.

Journal of biomedical semantics Nov 13, 2017
BACKGROUND: An experimental protocol is a sequence of tasks and operations executed to perform experimental research in biological and biomedical areas, e.g. biology, genetics, immunology, neurosciences, virology. Protocols often include references t...
Humans Semantic Web Internet Information Dissemination Information Storage and Retrieval Semantics Animals Terminology as Topic Biological Ontologies Models, Theoretical Evidence-Based Medicine
View on PubMed DOI

Drug target ontology to classify and integrate drug discovery data.

Journal of biomedical semantics Nov 9, 2017
BACKGROUND: One of the most successful approaches to develop new small molecule therapeutics has been to start from a validated druggable protein target. However, only a small subset of potentially druggable targets has attracted significant research...
Software Proteins Drug Delivery Systems Semantics Humans Biological Ontologies Drug Discovery Computational Biology
View on PubMed DOI

Identifying Human Phenotype Terms by Combining Machine Learning and Validation Rules.

BioMed research international Nov 9, 2017
Named-Entity Recognition is commonly used to identify biological entities such as proteins, genes, and chemical compounds found in scientific articles. The Human Phenotype Ontology (HPO) is an ontology that provides a standardized vocabulary for phen...
Phenotype Data Mining Humans Reproducibility of Results Machine Learning Biological Ontologies
View on PubMed DOI

Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China.

Scientific reports Oct 23, 2017
With increased usage of cardiovascular drugs (CVDs) for treating cardiovascular diseases, it is important to analyze CVD-associated adverse events (AEs). In this study, we systematically collected package insert-reported AEs associated with CVDs used...
Humans Product Labeling China Cardiovascular Diseases Biological Ontologies Data Interpretation, Statistical Medicine, Chinese Traditional Cardiovascular Agents Drug-Related Side Effects and Adverse Reactions
View on PubMed DOI

Prediction of Human Phenotype Ontology terms by means of hierarchical ensemble methods.

BMC bioinformatics Oct 12, 2017
BACKGROUND: The prediction of human gene-abnormal phenotype associations is a fundamental step toward the discovery of novel genes associated with human disorders, especially when no genes are known to be associated with a specific disease. In this c...
Humans Phenotype ROC Curve Algorithms Genetic Association Studies Biological Ontologies Area Under Curve Molecular Sequence Annotation
View on PubMed DOI

Taxonomy-Based Approaches to Quality Assurance of Ontologies.

Journal of healthcare engineering Oct 11, 2017
Ontologies are important components of health information management systems. As such, the quality of their content is of paramount importance. It has been proven to be practical to develop quality assurance (QA) methodologies based on automated iden...
Classification Quality Assurance, Health Care Humans Biological Ontologies
View on PubMed DOI

A new synonym-substitution method to enrich the human phenotype ontology.

BMC bioinformatics Oct 10, 2017
BACKGROUND: Named entity recognition is critical for biomedical text mining, where it is not unusual to find entities labeled by a wide range of different terms. Nowadays, ontologies are one of the crucial enabling technologies in bioinformatics, pro...
Humans Phenotype Semantics Biological Ontologies Data Mining
View on PubMed DOI

Querying clinical data in HL7 RIM based relational model with morph-RDB.

Journal of biomedical semantics Oct 5, 2017
BACKGROUND: Semantic interoperability is essential when carrying out post-genomic clinical trials where several institutions collaborate, since researchers and developers need to have an integrated view and access to heterogeneous data sources. One p...
Algorithms Databases, Factual Humans Software Semantics Biological Ontologies Internet Information Storage and Retrieval
View on PubMed DOI

Semantic annotation in biomedicine: the current landscape.

Journal of biomedical semantics Sep 22, 2017
The abundance and unstructured nature of biomedical texts, be it clinical or research content, impose significant challenges for the effective and efficient use of information and knowledge stored in such texts. Annotation of biomedical documents wit...
Biological Ontologies Information Storage and Retrieval Semantics Electronic Health Records Biomedical Research Humans
View on PubMed DOI

Investigations on factors influencing HPO-based semantic similarity calculation.

Journal of biomedical semantics Sep 20, 2017
BACKGROUND: Although disease diagnosis has greatly benefited from next generation sequencing technologies, it is still difficult to make the right diagnosis purely based on sequencing technologies for many diseases with complex phenotypes and high ge...
Algorithms Phenotype Humans Biological Ontologies Molecular Sequence Annotation Computational Biology Semantics
View on PubMed DOI
Popular Topics
Recent Journals