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Calcium Channels, L-Type

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The effect of cinnamon extract on isolated rat uterine strips.

Reproductive biology
Cinnamon is a spice used by some populations as a traditional remedy to control blood pressure and thus hypertension. Cinnamon extract decreases contractility in some smooth muscles, but its effect on uterine smooth muscle is unknown. The aim of this...

Artificial intelligence-driven identification of morin analogues acting as Ca1.2 channel blockers: Synthesis and biological evaluation.

Bioorganic chemistry
Morin is a vasorelaxant flavonoid, whose activity is ascribable to Ca1.2 channel blockade that, however, is weak as compared to that of clinically used therapeutic agents. A conventional strategy to circumvent this drawback is to synthesize new deriv...

CardioDPi: An explainable deep-learning model for identifying cardiotoxic chemicals targeting hERG, Cav1.2, and Nav1.5 channels.

Journal of hazardous materials
The cardiotoxic effects of various pollutants have been a growing concern in environmental and material science. These effects encompass arrhythmias, myocardial injury, cardiac insufficiency, and pericardial inflammation. Compounds such as organic so...