AIMC Topic: Calcium Channels, L-Type
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CardioDPi: An explainable deep-learning model for identifying cardiotoxic chemicals targeting hERG, Cav1.2, and Nav1.5 channels.
Journal of hazardous materials
May 24, 2024
The cardiotoxic effects of various pollutants have been a growing concern in environmental and material science. These effects encompass arrhythmias, myocardial injury, cardiac insufficiency, and pericardial inflammation. Compounds such as organic so...
Artificial intelligence-driven identification of morin analogues acting as Ca1.2 channel blockers: Synthesis and biological evaluation.
Bioorganic chemistry
Dec 17, 2022
Morin is a vasorelaxant flavonoid, whose activity is ascribable to Ca1.2 channel blockade that, however, is weak as compared to that of clinically used therapeutic agents. A conventional strategy to circumvent this drawback is to synthesize new deriv...
The effect of cinnamon extract on isolated rat uterine strips.
Reproductive biology
Dec 17, 2015
Cinnamon is a spice used by some populations as a traditional remedy to control blood pressure and thus hypertension. Cinnamon extract decreases contractility in some smooth muscles, but its effect on uterine smooth muscle is unknown. The aim of this...
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