AIMC Topic: Calcium Channel Blockers
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Natural language processing of electronic medical records identifies cardioprotective agents for anthracycline induced cardiotoxicity.
Scientific reports
Feb 24, 2025
In this retrospective observational study, we aimed to investigate the potential of natural language processing (NLP) for drug repositioning by analyzing the preventive effects of cardioprotective drugs against anthracycline-induced cardiotoxicity (A...
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Cardiotonic Agents
Cardiotoxicity
Drug Repositioning
Natural Language Processing
Calcium Channel Blockers
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anthracyclines
Adrenergic beta-Antagonists
Humans
Retrospective Studies
Electronic Health Records
Adult
Male
Middle Aged
Female
Aged
CaBind_MCNN: Identifying Potential Calcium Channel Blocker Targets by Predicting Calcium-Binding Sites in Ion Channels and Ion Transporters Using Protein Language Models and Multiscale Feature Extraction.
Journal of chemical information and modeling
Feb 6, 2025
Calcium ions (Ca) are crucial for various physiological processes, including neurotransmission and cardiac function. Dysregulation of Ca homeostasis can lead to serious health conditions such as cardiac arrhythmias and hypertension. Ion channels and ...
Cocrystal Prediction of Nifedipine Based on the Graph Neural Network and Molecular Electrostatic Potential Surface.
AAPS PharmSciTech
Jun 11, 2024
Nifedipine (NIF) is a dihydropyridine calcium channel blocker primarily used to treat conditions such as hypertension and angina. However, its low solubility and low bioavailability limit its effectiveness in clinical practice. Here, we developed a c...
Deep learning neural network derivation and testing to distinguish acute poisonings.
Expert opinion on drug metabolism & toxicology
Jul 17, 2023
INTRODUCTION: Acute poisoning is a significant global health burden, and the causative agent is often unclear. The primary aim of this pilot study was to develop a deep learning algorithm that predicts the most probable agent a poisoned patient was e...
Artificial intelligence-driven identification of morin analogues acting as Ca1.2 channel blockers: Synthesis and biological evaluation.
Bioorganic chemistry
Dec 17, 2022
Morin is a vasorelaxant flavonoid, whose activity is ascribable to Ca1.2 channel blockade that, however, is weak as compared to that of clinically used therapeutic agents. A conventional strategy to circumvent this drawback is to synthesize new deriv...
Natural Language Processing for Rapid Response to Emergent Diseases: Case Study of Calcium Channel Blockers and Hypertension in the COVID-19 Pandemic.
Journal of medical Internet research
Aug 14, 2020
BACKGROUND: A novel disease poses special challenges for informatics solutions. Biomedical informatics relies for the most part on structured data, which require a preexisting data or knowledge model; however, novel diseases do not have preexisting k...
Effect of Switching from Cilnidipine to Azelnidipine on Cardiac Sympathetic Nerve Function in Patients with Heart Failure Preserved Ejection Fraction.
International heart journal
Dec 20, 2017
Cardiac sympathetic nerve activity is known to play a key role in the development and progression of heart failure (HF). Azelnidipine, an L-type calcium channel blocker (CCB), inhibits the sympathetic nerve activity of the central system. In contrast...
Middle Aged
Treatment Outcome
Follow-Up Studies
Dose-Response Relationship, Drug
Drug Substitution
Calcium Channel Blockers
Radionuclide Imaging
Heart
Heart Failure
Adult
Male
Azetidinecarboxylic Acid
Humans
Stroke Volume
Dihydropyridines
Echocardiography
Retrospective Studies
Sympathetic Nervous System
Female
Aged
Aged, 80 and over
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Poloxamer
Polysorbates
Surface Properties
Calcium Channel Blockers
Chemistry, Pharmaceutical
Lipids
Delayed-Action Preparations
Drug Carriers
Models, Chemical
Polymers
Algorithms
Solubility
Computer Simulation
Nanomedicine
Kinetics
Nanoparticles
Neural Networks, Computer
Technology, Pharmaceutical
Verapamil
Particle Size
Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta.
Pakistan journal of pharmaceutical sciences
Nov 1, 2019
Hypertension is persistent elevation in blood pressure for 3-4 weeks. Estimated global prevalence of hypertension suggested that by the Year 2025 (29%) of adult worldwide are suffering from hypertension (1.56 billion). Hypertension complications are ...
Spasmolytic activity of Aquilariae Lignum Resinatum extract on gastrointestinal motility involves muscarinic receptors, calcium channels and NO release.
Pharmaceutical biology
Dec 1, 2018
CONTEXT: Aquilariae Lignum Resinatum (ALR), the dry rhizome of Aquilaria agallocha R. (Thymelaeaeeae), has been widely used to treat emesis, stomachache and gastrointestinal dysfunction.
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