AIMC Topic: Cell Lineage

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Quantitative Modelling of the Waddington Epigenetic Landscape.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2019
C.H. Waddington introduced the epigenetic landscape as a metaphor to represent cellular decision-making during development. Like a population of balls rolling down a rough hillside, developing cells follow specific trajectories (valleys) and eventual...
Humans Neural Networks, Computer Phenotype Gene Regulatory Networks Epigenomics Models, Genetic Stem Cells Cell Differentiation Cell Lineage
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Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.

Nucleic acids research Dec 1, 2017
Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteome diversity. Comprehensively decoding these regulatory mechanisms holds promise in getting deeper insights into a variety...
Humans Neural Networks, Computer Machine Learning Sequence Analysis, RNA Epigenesis, Genetic Cell Line Cell Differentiation High-Throughput Nucleotide Sequencing Tumor Suppressor Proteins Ubiquitin-Protein Ligases Cell Lineage Alternative Splicing Embryonic Stem Cells Histone Code
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