AIMC Topic: Cell Nucleus

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Leukocyte deep learning classification assessment using Shapley additive explanations algorithm.

International journal of laboratory hematology
INTRODUCTION: A peripheral blood smear is a basic test for hematological disease diagnosis. This test is performed manually in many places worldwide, which requires both time and qualified staff. Large laboratories are equipped with digital morpholog...

Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy.

Communications biology
Bioluminescence microscopy is an appealing alternative to fluorescence microscopy, because it does not depend on external illumination, and consequently does neither produce spurious background autofluorescence, nor perturb intrinsically photosensiti...

UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues.

Communications biology
Upcoming technologies enable routine collection of highly multiplexed (20-60 channel), subcellular resolution images of mammalian tissues for research and diagnosis. Extracting single cell data from such images requires accurate image segmentation, a...

FEEDNet: a feature enhanced encoder-decoder LSTM network for nuclei instance segmentation for histopathological diagnosis.

Physics in medicine and biology
Automated cell nuclei segmentation is vital for the histopathological diagnosis of cancer. However, nuclei segmentation from 'hematoxylin and eosin' (HE) stained 'whole slide images' (WSIs) remains a challenge due to noise-induced intensity variation...

Transfer Learning Approach and Nucleus Segmentation with MedCLNet Colon Cancer Database.

Journal of digital imaging
Machine learning has been recently used especially in the medical field. In the diagnosis of serious diseases such as cancer, deep learning techniques can be used to reduce the workload of experts and to produce quick solutions. The nuclei found in t...

Usability of deep learning pipelines for 3D nuclei identification with Stardist and Cellpose.

Cells & development
Segmentation of 3D images to identify cells and their molecular outputs can be difficult and tedious. Machine learning algorithms provide a promising alternative to manual analysis as emerging 3D image processing technology can save considerable time...

Detecting and Classifying Nuclei Using Multi-Scale Fully Convolutional Network.

Journal of computational biology : a journal of computational molecular cell biology
The detection and classification of nuclei play an important role in the histopathological analysis. It aims to find out the distribution of nuclei in the histopathology images for the next step of analysis and research. However, it is very challengi...

Attention Mask R-CNN with edge refinement algorithm for identifying circulating genetically abnormal cells.

Cytometry. Part A : the journal of the International Society for Analytical Cytology
Recent studies have suggested that circulating tumor cells with abnormalities in gene copy numbers in mononuclear cell-enriched peripheral blood samples, such as circulating genetically abnormal cells (CACs), can be used as a non-invasive tool to det...

Application of the sliding window method and Mask-RCNN method to nuclear recognition in oral cytology.

Diagnostic pathology
BACKGROUND: We aimed to develop an artificial intelligence (AI)-assisted oral cytology method, similar to cervical cytology. We focused on the detection of cell nuclei because the ratio of cell nuclei to cytoplasm increases with increasing cell malig...

Marker-controlled watershed with deep edge emphasis and optimized H-minima transform for automatic segmentation of densely cultivated 3D cell nuclei.

BMC bioinformatics
BACKGROUND: The segmentation of 3D cell nuclei is essential in many tasks, such as targeted molecular radiotherapies (MRT) for metastatic tumours, toxicity screening, and the observation of proliferating cells. In recent years, one popular method for...