AIMC Topic:
Computer Simulation

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A strategy for mapping biophysical to abstract neuronal network models applied to primary visual cortex.

PLoS computational biology Aug 16, 2021
A fundamental challenge for the theoretical study of neuronal networks is to make the link between complex biophysical models based directly on experimental data, to progressively simpler mathematical models that allow the derivation of general opera...
Visual Cortex Electrophysiological Phenomena Synapses Biophysical Phenomena Nerve Net Brain Mapping Kinetics Neurons Humans Neural Networks, Computer Computational Biology Models, Neurological Computer Simulation Animals
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Fuzzy adaptive fault diagnosis and compensation for variable structure hypersonic vehicle with multiple faults.

PloS one Aug 13, 2021
Based on the type-II fuzzy logic, this paper proposes a robust adaptive fault diagnosis and fault-tolerant control (FTC) scheme for multisensor faults in the variable structure hypersonic vehicles with parameter uncertainties. Type-II fuzzy method ap...
Unmanned Aerial Devices Models, Statistical Nonlinear Dynamics Uncertainty Humans Computer Simulation Fuzzy Logic
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Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space.

PLoS computational biology Aug 12, 2021
Navigation of fast migrating cells such as amoeba Dictyostelium and immune cells are tightly associated with their morphologies that range from steady polarized forms that support high directionality to those more complex and variable when making fre...
Models, Biological Cichlids HL-60 Cells Computational Biology Cell Movement Fibroblasts Cell Surface Extensions Cell Shape Cell Polarity Dictyostelium Humans Animals Deep Learning Cells, Cultured Computer Simulation
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Memristor-Based Neural Network Circuit of Emotion Congruent Memory With Mental Fatigue and Emotion Inhibition.

IEEE transactions on biomedical circuits and systems Aug 12, 2021
Most memristor-based neural networks only consider a single mode of memory or emotion, but ignore the relationship between emotion and memory. In this paper, a memristor-based neural network circuit of emotion congruent memory is proposed and verifie...
Learning Emotions Mental Fatigue Humans Neural Networks, Computer Computer Simulation
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Structured patterns of activity in pulse-coupled oscillator networks with varied connectivity.

PloS one Aug 11, 2021
Identifying coordinated activity within complex systems is essential to linking their structure and function. We study collective activity in networks of pulse-coupled oscillators that have variable network connectivity and integrate-and-fire dynamic...
Humans Neural Networks, Computer Neural Pathways Nerve Net Computer Simulation Models, Neurological
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Machine learning model for early prediction of acute kidney injury (AKI) in pediatric critical care.

Critical care (London, England) Aug 10, 2021
BACKGROUND: Acute kidney injury (AKI) in pediatric critical care patients is diagnosed using elevated serum creatinine, which occurs only after kidney impairment. There are no treatments other than supportive care for AKI once it has developed, so it...
Humans Machine Learning Computer Simulation Area Under Curve Critical Care Pediatrics Severity of Illness Index Adolescent Cohort Studies Intensive Care Units, Pediatric ROC Curve Child, Preschool Child Young Adult Male Infant Acute Kidney Injury Female Infant, Newborn
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A novel two-step approach for optimal groundwater remediation by coupling extreme learning machine with evolutionary hunting strategy based metaheuristics.

Journal of contaminant hydrology Aug 9, 2021
We propose a simulation-optimization (SO) model based on a novel two-step strategy for the optimal design of groundwater remediation systems. The SO models are developed by coupling simulation models directly or through the extreme learning machine (...
Environmental Restoration and Remediation Water Purification Computer Simulation Groundwater Machine Learning
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Machine-learning model selection and parameter estimation from kinetic data of complex first-order reaction systems.

PloS one Aug 9, 2021
Dealing with a system of first-order reactions is a recurrent issue in chemometrics, especially in the analysis of data obtained by spectroscopic methods applied on complex biological systems. We argue that global multiexponential fitting, the still ...
Computer Simulation Computational Biology Bayes Theorem Machine Learning Software Data Analysis Flavin-Adenine Dinucleotide Kinetics Models, Biological Bacteriorhodopsins
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Interpretable deep recommender system model for prediction of kinase inhibitor efficacy across cancer cell lines.

Scientific reports Aug 6, 2021
Computational models for drug sensitivity prediction have the potential to significantly improve personalized cancer medicine. Drug sensitivity assays, combined with profiling of cancer cell lines and drugs become increasingly available for training ...
Humans Algorithms Computer Simulation Deep Learning Gene Expression Regulation, Neoplastic Protein Kinase Inhibitors Tumor Cells, Cultured Prognosis Biomarkers, Tumor Neoplasms
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KenDTI: An Ensemble Model for Predicting Drug-Target Interaction by Integrating Multi-Source Information.

IEEE/ACM transactions on computational biology and bioinformatics Aug 6, 2021
The identification of drug-target interactions (DTIs) is an essential step in the process of drug discovery. As experimental validation suffers from high cost and low success rate, various computational models have been exploited to infer potential D...
Algorithms Computer Simulation Computational Biology Databases, Protein Natural Language Processing Drug Development Proteins Humans Neural Networks, Computer Software Pharmaceutical Preparations Databases, Pharmaceutical
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