AIMC Topic: Cytochrome P-450 CYP2C9

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Evaluation of machine learning models for cytochrome P450 3A4, 2D6, and 2C9 inhibition.

Journal of applied toxicology : JAT Mar 27, 2024
Cytochrome P450 (CYP) enzymes are involved in the metabolism of approximately 75% of marketed drugs. Inhibition of the major drug-metabolizing P450s could alter drug metabolism and lead to undesirable drug-drug interactions. Therefore, it is of great...
Humans Machine Learning Algorithms Computer Simulation Deep Learning Cytochrome P-450 CYP3A Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 CYP2D6 Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors
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Prediction of Cytochrome P450 Inhibition Using a Deep Learning Approach and Substructure Pattern Recognition.

Journal of chemical information and modeling Oct 21, 2023
Cytochrome P450 (CYP) is a family of enzymes that are responsible for about 75% of all metabolic reactions. Among them, CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 participate in the metabolism of most drugs and mediate many adverse drug reactions. T...
Deep Learning Microsomes, Liver Cytochrome P-450 Enzyme System Cytochrome P-450 CYP3A Protein Isoforms Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 CYP2D6 Cytochrome P-450 CYP1A2
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Machine learning-driven identification of drugs inhibiting cytochrome P450 2C9.

PLoS computational biology Jan 26, 2022
Cytochrome P450 2C9 (CYP2C9) is a major drug-metabolizing enzyme that represents 20% of the hepatic CYPs and is responsible for the metabolism of 15% of drugs. A general concern in drug discovery is to avoid the inhibition of CYP leading to toxic dru...
Humans Machine Learning Computational Biology Drug Interactions Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme Inhibitors
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Artificial neural network-based pharmacogenomic algorithm for warfarin dose optimization.

Pharmacogenomics Dec 15, 2015
AIM: To develop more precise pharmacogenomic algorithm for prediction of safe and effective dose of warfarin.
Humans Neural Networks, Computer Algorithms Female Young Adult Adult Male Middle Aged Anticoagulants Warfarin Models, Biological Stereoisomerism Cytochrome P-450 CYP2C9
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