AIMC Topic: Cytokinesis
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Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning.
Archives of toxicology
Jul 10, 2021
The in vitro micronucleus assay is a globally significant method for DNA damage quantification used for regulatory compound safety testing in addition to inter-individual monitoring of environmental, lifestyle and occupational factors. However, it re...
The in vitro micronucleus assay using imaging flow cytometry and deep learning.
NPJ systems biology and applications
May 18, 2021
The in vitro micronucleus (MN) assay is a well-established assay for quantification of DNA damage, and is required by regulatory bodies worldwide to screen chemicals for genetic toxicity. The MN assay is performed in two variations: scoring MN in cyt...
Automated Triage Radiation Biodosimetry: Integrating Imaging Flow Cytometry with High-Throughput Robotics to Perform the Cytokinesis-Block Micronucleus Assay.
Radiation research
Feb 19, 2019
The cytokinesis-block micronucleus (CBMN) assay has become a fully-validated and standardized method for radiation biodosimetry. The assay is typically performed using microscopy, which is labor intensive, time consuming and impractical after a large...
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