AIMC Topic: Dose-Response Relationship, Radiation

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A competing risks machine learning study of neutron dose, fractionation, age, and sex effects on mortality in 21,000 mice.

Scientific reports
This study explores the impact of densely-ionizing radiation on non-cancer and cancer diseases, focusing on dose, fractionation, age, and sex effects. Using historical mortality data from approximately 21,000 mice exposed to fission neutrons, we empl...

Radiation dose estimation with multiple artificial neural networks in dicentric chromosome assay.

International journal of radiation biology
PURPOSE: The dicentric chromosome assay (DCA), often referred to as the 'gold standard' in radiation dose estimation, exhibits significant challenges as a consequence of its labor-intensive nature and dependency on expert knowledge. Existing automate...

Using Deep Learning to Predict Treatment Response in Patients with Hepatocellular Carcinoma Treated with Y90 Radiation Segmentectomy.

Journal of digital imaging
Treatment of hepatocellular carcinoma (HCC) with Y90 radioembolization segmentectomy (Y90-RE) demonstrates a tumor dose-response threshold, where dose estimates are highly dependent on accurate SPECT/CT acquisition, registration, and reconstruction. ...

Dicentric chromosome assay using a deep learning-based automated system.

Scientific reports
The dicentric chromosome assay is the "gold standard" in biodosimetry for estimating radiation exposure. However, its large-scale deployment is limited owing to its time-consuming nature and requirement for expert reviewers. Therefore, a recently dev...

Automatic multi-organ segmentation in dual-energy CT (DECT) with dedicated 3D fully convolutional DECT networks.

Medical physics
PURPOSE: Dual-energy computed tomography (DECT) has shown great potential in many clinical applications. By incorporating the information from two different energy spectra, DECT provides higher contrast and reveals more material differences of tissue...

Automated Triage Radiation Biodosimetry: Integrating Imaging Flow Cytometry with High-Throughput Robotics to Perform the Cytokinesis-Block Micronucleus Assay.

Radiation research
The cytokinesis-block micronucleus (CBMN) assay has become a fully-validated and standardized method for radiation biodosimetry. The assay is typically performed using microscopy, which is labor intensive, time consuming and impractical after a large...

Optimization of goose breast meat tenderness by rapid ultrasound treatment using response surface methodology and artificial neural network.

Animal science journal = Nihon chikusan Gakkaiho
The aim of this study was to develop a prediction model on tenderization of goose breast meat by response surface methodology (RSM) and artificial neural network (ANN). The experiments were operated on the basis of a three-level, three-variable (ultr...

Expert system classifier for adaptive radiation therapy in prostate cancer.

Australasian physical & engineering sciences in medicine
A classifier-based expert system was developed to compare delivered and planned radiation therapy in prostate cancer patients. Its aim is to automatically identify patients that can benefit from an adaptive treatment strategy. The study predominantly...

Evaluation of a Machine-Learning Algorithm for Treatment Planning in Prostate Low-Dose-Rate Brachytherapy.

International journal of radiation oncology, biology, physics
PURPOSE: This work presents the application of a machine learning (ML) algorithm to automatically generate high-quality, prostate low-dose-rate (LDR) brachytherapy treatment plans. The ML algorithm can mimic characteristics of preoperative treatment ...

The use of natural language processing on narrative medication schedules to compute average weekly dose.

Pharmacoepidemiology and drug safety
PURPOSE: Medications with non-standard dosing and unstandardized units of measurement make the estimation of prescribed dose difficult from pharmacy dispensing data. A natural language processing tool named the SIG extractor was developed to identify...