Multi-template polymerase chain reaction (PCR) is a critical technique enabling the parallel amplification of diverse DNA molecules, thereby facilitating applications in fields from quantitative molecular biology to DNA data storage. However, non-hom...
The mutational outcome of DNA damage as a direct result of constant chemical assault is governed by major factors, including the structure and nature of damage, replication, and repair machinery . The role of the size of the adduct, adduct-flanking b...
As potential biomarkers for breast cancer, microRNAs (miRNAs) have demonstrated significant promise in clinical applications. However, accurate miRNA-based breast cancer diagnosis is hindered by the lack of simple, ultrasensitive, and highly specific...
Machine learning (ML) is increasingly used in DNA-encoded library (DEL) screening for ligand discovery, but its success depends on access to suitable data sets, which are often proprietary and costly. To overcome this, we present the first fully open...
DNA nanotechnology uses predictable interactions of nucleic acids to precisely engineer complex nanostructures. Characterizing these self-assembled structures at the single-structure level is crucial for validating their design and functionality. Nan...
Over the past 15 years, a variety of next-generation sequencing assays have been developed for measuring the 3D conformation of DNA in the nucleus. Each of these assays gives, for a particular cell or tissue type, a distinct picture of 3D chromatin a...
Recent advances in green nanomaterials have primarily focused on mitigating toxicity through passive approaches, yet emerging technologies suggest a transformative paradigm shift toward programmable nanomaterials with dynamic biointerfaces. This Revi...
Detecting single point mutations, such as PIK3CA mutations, is vital for precision diagnostics but remains challenging due to subtle sequence differences. This study introduces a machine learning-assisted colorimetric biosensor that utilizes DNA-temp...
Journal of chemical information and modeling
Sep 15, 2025
Tools available for analyzing next-generation sequencing (NGS) data produced from DNA-encoded library (DEL) screening campaigns are often constrained to customized methods developed internally by individual institutes, which usually generate data spe...
Journal of chemical information and modeling
Sep 7, 2025
Transcription factors (TFs) are essential proteins that regulate gene expression by specifically binding to transcription factor binding sites (TFBSs) within DNA sequences. Their ability to precisely control the transcription process is crucial for u...
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