AIMC Topic: Epitopes, B-Lymphocyte
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VirusImmu: a novel ensemble machine learning approach for viral immunogenicity prediction.
Briefings in functional genomics
Jan 15, 2025
The viruses threats provoke concerns regarding their sustained epidemic transmission, making the development of vaccines particularly important. In the prolonged and costly process of vaccine development, the most important initial step is to identif...
An Integrated Approach to Develop a Potent Vaccine Candidate Construct Against Prostate Cancer by Utilizing Machine Learning and Bioinformatics.
Cancer reports (Hoboken, N.J.)
Dec 1, 2024
BACKGROUND: Prostate cancer is the most common malignancy among males. Prostaglandin G/H synthase (PGHS) is an essential enzyme in the synthesis of prostaglandins, and its activation has been linked to many malignancies, including colorectal cancer.
Identifying B-cell epitopes using AlphaFold2 predicted structures and pretrained language model.
Bioinformatics (Oxford, England)
Apr 3, 2023
MOTIVATION: Identifying the B-cell epitopes is an essential step for guiding rational vaccine development and immunotherapies. Since experimental approaches are expensive and time-consuming, many computational methods have been designed to assist B-c...
epitope3D: a machine learning method for conformational B-cell epitope prediction.
Briefings in bioinformatics
Jan 17, 2022
The ability to identify antigenic determinants of pathogens, or epitopes, is fundamental to guide rational vaccine development and immunotherapies, which are particularly relevant for rapid pandemic response. A range of computational tools has been d...
Organism-specific training improves performance of linear B-cell epitope prediction.
Bioinformatics (Oxford, England)
Dec 11, 2021
MOTIVATION: In silico identification of linear B-cell epitopes represents an important step in the development of diagnostic tests and vaccine candidates, by providing potential high-probability targets for experimental investigation. Current predict...
Improvement in prediction of antigenic epitopes using stacked generalisation: an ensemble approach.
IET systems biology
Feb 1, 2020
The major intent of peptide vaccine designs, immunodiagnosis and antibody productions is to accurately identify linear B-cell epitopes. The determination of epitopes through experimental analysis is highly expensive. Therefore, it is desirable to dev...
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