AIMC Topic: Vaccines, Subunit

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Reverse engineering protection: A comprehensive survey of reverse vaccinology-based vaccines targeting viral pathogens.

Vaccine Mar 23, 2024
Vaccines have significantly reduced the impact of numerous deadly viral infections. However, there is an increasing need to expedite vaccine development in light of the recurrent pandemics and epidemics. Also, identifying vaccines against certain vir...
Artificial Intelligence Epitopes, T-Lymphocyte Molecular Docking Simulation Humans Vaccines Epitopes, B-Lymphocyte Vaccines, Subunit Computational Biology Proteome Epitopes Vaccinology
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Identification of vaccine targets & design of vaccine against SARS-CoV-2 coronavirus using computational and deep learning-based approaches.

PeerJ May 19, 2022
An unusual pneumonia infection, named COVID-19, was reported on December 2019 in China. It was reported to be caused by a novel coronavirus which has infected approximately 220 million people worldwide with a death toll of 4.5 million as of September...
Vaccines, Subunit Molecular Docking Simulation Deep Learning COVID-19 Vaccines Escherichia coli Epitopes, B-Lymphocyte COVID-19 SARS-CoV-2 Viral Vaccines Humans
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An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study.

Scientific reports Feb 5, 2021
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical the...
Codon Usage Immunogenicity, Vaccine Deep Learning Humans T-Lymphocytes, Helper-Inducer Epitopes, T-Lymphocyte Spike Glycoprotein, Coronavirus COVID-19 Molecular Dynamics Simulation COVID-19 Vaccines Molecular Docking Simulation Mutation Protein Conformation Epitopes, B-Lymphocyte Allergens Drug Design SARS-CoV-2 Solubility Vaccines, Subunit T-Lymphocytes, Cytotoxic Computational Biology Models, Molecular RNA, Viral
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Predicted Cellular Immunity Population Coverage Gaps for SARS-CoV-2 Subunit Vaccines and Their Augmentation by Compact Peptide Sets.

Cell systems Nov 27, 2020
Subunit vaccines induce immunity to a pathogen by presenting a component of the pathogen and thus inherently limit the representation of pathogen peptides for cellular immunity-based memory. We find that severe acute respiratory syndrome coronavirus ...
Humans COVID-19 Vaccines Machine Learning COVID-19 Vaccines, Subunit Forecasting Immunity, Cellular
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Enhancing the Biological Relevance of Machine Learning Classifiers for Reverse Vaccinology.

International journal of molecular sciences Feb 1, 2017
Reverse vaccinology (RV) is a bioinformatics approach that can predict antigens with protective potential from the protein coding genomes of bacterial pathogens for subunit vaccine design. RV has become firmly established following the development of...
Area Under Curve Epitopes Humans Bacterial Vaccines ROC Curve Epitope Mapping Computational Biology Support Vector Machine Mutagenesis Antigens, Bacterial Vaccines, Subunit Machine Learning Bacterial Proteins
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Application of in-silico approaches in subunit vaccines: Overcoming the challenges of antigen and adjuvant development.

Journal of controlled release : official journal of the Controlled Release Society May 10, 2025
Subunit vaccines are crucial in preventing modern diseases due to their safety, stability, and ability to elicit targeted immune responses. However, challenges in antigen and adjuvant design hinder their development. Recent advancements in in-silico ...
Humans Machine Learning Computer Simulation Antigens Vaccines, Subunit Vaccinology Animals Vaccine Development Adjuvants, Immunologic
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An Integrated Approach to Develop a Potent Vaccine Candidate Construct Against Prostate Cancer by Utilizing Machine Learning and Bioinformatics.

Cancer reports (Hoboken, N.J.) Dec 1, 2024
BACKGROUND: Prostate cancer is the most common malignancy among males. Prostaglandin G/H synthase (PGHS) is an essential enzyme in the synthesis of prostaglandins, and its activation has been linked to many malignancies, including colorectal cancer.
Molecular Docking Simulation Computational Biology Cancer Vaccines Epitopes, B-Lymphocyte Vaccine Development Vaccines, Subunit Prostatic Neoplasms Molecular Dynamics Simulation Machine Learning Male Epitopes, T-Lymphocyte Humans
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