AIMC Topic: Extracellular Signal-Regulated MAP Kinases

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Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements.

Nature communications May 21, 2025
The RAS/ERK pathway plays a central role in diagnosis and therapy for many cancers. ERK activity is highly dynamic within individual cells and drives cell proliferation, metabolism, and other processes through effector proteins including c-Myc, c-Fos...
Humans Machine Learning Cell Line, Tumor Biosensing Techniques MAP Kinase Signaling System Fluorescent Antibody Technique Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-myc Extracellular Signal-Regulated MAP Kinases Early Growth Response Protein 1
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CODEX, a neural network approach to explore signaling dynamics landscapes.

Molecular systems biology Apr 1, 2021
Current studies of cell signaling dynamics that use live cell fluorescent biosensors routinely yield thousands of single-cell, heterogeneous, multi-dimensional trajectories. Typically, the extraction of relevant information from time series data reli...
Humans Neural Networks, Computer Machine Learning Algorithms Animals Signal Transduction Cell Line Fluorescent Dyes Proto-Oncogene Proteins c-akt Transforming Growth Factor beta Light Intercellular Signaling Peptides and Proteins Tumor Suppressor Protein p53 Databases as Topic Movement Dose-Response Relationship, Radiation Drosophila Radiation, Ionizing Extracellular Signal-Regulated MAP Kinases
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