AIMC Topic: Proto-Oncogene Proteins c-fos

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Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements.

Nature communications May 21, 2025
The RAS/ERK pathway plays a central role in diagnosis and therapy for many cancers. ERK activity is highly dynamic within individual cells and drives cell proliferation, metabolism, and other processes through effector proteins including c-Myc, c-Fos...
Machine Learning Cell Line, Tumor Humans Fluorescent Antibody Technique Proto-Oncogene Proteins c-fos Biosensing Techniques MAP Kinase Signaling System Extracellular Signal-Regulated MAP Kinases Early Growth Response Protein 1 Proto-Oncogene Proteins c-myc
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Comparative analysis of functional network dynamics in high and low alcohol preference mice.

Experimental neurology Apr 4, 2025
Individual variability preference is a typical characteristic of alcohol drinking behaviors, with a higher risk for the development of alcohol use disorders (AUDs) in high alcohol preference (HP) populations. Here, we created a map of alcohol-related...
Brain Animals Mice, Inbred C57BL Male Alcohol Drinking Mice Ethanol Proto-Oncogene Proteins c-fos Ventral Tegmental Area Neural Pathways Nerve Net
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Virtual reality-empowered deep-learning analysis of brain cells.

Nature methods Apr 22, 2024
Automated detection of specific cells in three-dimensional datasets such as whole-brain light-sheet image stacks is challenging. Here, we present DELiVR, a virtual reality-trained deep-learning pipeline for detecting c-Fos cells as markers for neuron...
Image Processing, Computer-Assisted Mice Neurons Proto-Oncogene Proteins c-fos Deep Learning Virtual Reality Animals Humans Software Brain
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Pancreatic cancer biomarker detection by two support vector strategies for recursive feature elimination.

Biomarkers in medicine Feb 15, 2019
AIM: Pancreatic cancer is one of the worst malignant tumors in prognosis. Therefore, to reduce the mortality rate of pancreatic cancer, early diagnosis and prompt treatment are particularly important.
Gene Expression Profiling Case-Control Studies Support Vector Machine Pancreatic Neoplasms Humans alpha-Macroglobulins Survival Rate Proto-Oncogene Proteins c-fos Algorithms Biomarkers, Tumor Matrix Metalloproteinase 7 Pancreas Prognosis
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Structural Comparison of Gene Relevance Networks for Breast Cancer Tissues in Different Grades.

Combinatorial chemistry & high throughput screening Jan 1, 2016
BACKGROUND: The breast is an important biological system of human with two distinct states, i.e. normal and tumoral. Research on breast cancer could be based on systematic modeling to contrast the system structures of these two states.
Genes, Neoplasm Gene Regulatory Networks ZAP-70 Protein-Tyrosine Kinase Proto-Oncogene Proteins c-fos ras Proteins Support Vector Machine bcl-2 Homologous Antagonist-Killer Protein Female Humans Lipocalin-2 Breast Neoplasms ErbB Receptors
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