AIMC Topic: Intercellular Signaling Peptides and Proteins
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Development and experimental validation of hypoxia-related gene signatures for osteosarcoma diagnosis and prognosis based on WGCNA and machine learning.
Scientific reports
Aug 12, 2024
Osteosarcoma (OS) is the most common primary malignant tumour of the bone with high mortality. Here, we comprehensively analysed the hypoxia signalling in OS and further constructed novel hypoxia-related gene signatures for OS prediction and prognosi...
Identifying as a Biomarker Covering Multiple Pathogenic Pathways for Diagnosing Heart Failure: From Machine Learning to Mechanism Interpretation.
Biomolecules
Feb 2, 2024
BACKGROUND: The pathophysiologic heterogeneity of heart failure (HF) necessitates a more detailed identification of diagnostic biomarkers that can reflect its diverse pathogenic pathways.
G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker, promotes proliferation and invasion of triple negative breast cancer.
Experimental and molecular pathology
Feb 2, 2022
We have identified the novel protein GASP-1 (G protein coupled receptor-associated sorting protein 1) that appears to be a universal cancer marker and the expression of which in tumor tissue and patient sera is predictive of cancer severity (Tuszynsk...
Decreased gremlin 1 expression in women with BMI ≥35 kg/m is mediated by interleukin 10 and interleukin 1β in the follicular fluid.
F&S science
Jun 29, 2020
OBJECTIVE: To determine how body mass index (BMI) affects the follicular fluid cytokine milieu and investigate how this inflammatory environment impacts cumulus signaling.
Growth Factor Delivery for the Repair of a Critical Size Tibia Defect Using an Acellular, Biodegradable Polyethylene Glycol-Albumin Hydrogel Implant.
ACS biomaterials science & engineering
Nov 5, 2019
Growth factor delivery using acellular matrices presents a promising alternative to current treatment options for bone repair in critical-size injuries. However, supra-physiological doses of the factors can introduce safety concerns that must be alle...
Serum Concentrations of New Predictive Cardiovascular Disease Biomarkers in Mexican Women Exposed to Lead.
Archives of environmental contamination and toxicology
Dec 20, 2017
The purpose of this study was to evaluate lead exposure and its relationship with serum levels of predictive CVD biomarkers [asymmetric dimethylarginine (ADMA), adipocyte fatty acid-binding protein (FABP4), adiponectin, and chemerin] in women living ...
Study of Structure-active Relationship for Inhibitors of HIV-1 Integrase LEDGF/p75 Interaction by Machine Learning Methods.
Molecular informatics
Feb 28, 2017
HIV-1 integrase (IN) is a promising target for anti-AIDS therapy, and LEDGF/p75 is proved to enhance the HIV-1 integrase strand transfer activity in vitro. Blocking the interaction between IN and LEDGF/p75 is an effective way to inhibit HIV replicati...
Optimized Repopulation of Tendon Hydrogel: Synergistic Effects of Growth Factor Combinations and Adipose-Derived Stem Cells.
Hand (New York, N.Y.)
Mar 15, 2016
Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation of the gel and that combinations ...
Downregulation of serum DKK-1 predicts poor prognosis in patients with papillary thyroid cancer.
Genetics and molecular research : GMR
Dec 29, 2015
The Wnt inhibitor dickkopf-1 (DKK-1) has been shown to be closely correlated with tumor initiation and progression in various types of cancers. However, the serum level of DKK-1 in patients with papillary thyroid cancer (PTC) and its potential clinic...
Humans
Carcinoma, Papillary
Thyroid Cancer, Papillary
Survival Analysis
Tumor Burden
Adolescent
Adult
Intercellular Signaling Peptides and Proteins
Thyroid Gland
Biomarkers, Tumor
Down-Regulation
Prognosis
Thyroid Neoplasms
Male
Neoplasm Staging
Female
Enzyme-Linked Immunosorbent Assay
Middle Aged
Carcinoma
Risk Factors
Lymphatic Metastasis
Case-Control Studies
Neoplasm Recurrence, Local
Aged
Gene Expression
Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer.
Genetics and molecular research : GMR
Dec 28, 2015
Dickkopf-1 (DKK-1) is a secreted protein that inhibits Wnt signaling. However, the clinical significance and prognostic value of serum DKK-1 levels have not been previously investigated in bladder cancer in Chinese patients. Blood samples were taken ...
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