AIMC Topic: gamma-Aminobutyric Acid

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Identifying responders to gabapentin for the treatment of alcohol use disorder: an exploratory machine learning approach.

Alcohol and alcoholism (Oxford, Oxfordshire)
BACKGROUND: Gabapentin, an anticonvulsant medication, has been proposed as a treatment for alcohol use disorder (AUD). A multisite study tested gabapentin enacarbil extended-release (GE-XR; 600 mg/twice a day), a prodrug formulation, combined with a ...

Understanding the role of astrocytic GABA in simulated neural networks.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Astrocytes actively influence the behavior of the surrounding neuronal network including changes of the synaptic plasticity and neuronal excitability. These dynamics are altered in diseases like Alzheimer's, where the release of the gliotransmitter G...