AIMC Topic: Hemagglutinin Glycoproteins, Influenza Virus

Clear Filters Showing 1 to 10 of 11 articles

Language models learn to represent antigenic properties of human influenza A(H3) virus.

Scientific reports Jul 1, 2025
Given that influenza vaccine effectiveness depends on a good antigenic match between the vaccine and circulating viruses, it is important to assess the antigenic properties of newly emerging variants continuously. With the increasing application of r...
Humans Machine Learning Antigens, Viral Influenza A Virus, H3N2 Subtype Hemagglutinin Glycoproteins, Influenza Virus Antigenic Variation Computer Simulation Deep Learning Influenza, Human
View on PubMed DOI

FluPMT: Prediction of Predominant Strains of Influenza A Viruses via Multi-Task Learning.

IEEE/ACM transactions on computational biology and bioinformatics Oct 9, 2024
Seasonal influenza vaccines play a crucial role in saving numerous lives annually. However, the constant evolution of the influenza A virus necessitates frequent vaccine updates to ensure its ongoing effectiveness. The decision to develop a new vacci...
Hemagglutinin Glycoproteins, Influenza Virus Evolution, Molecular Influenza, Human Influenza Vaccines Humans Influenza A virus Machine Learning Computational Biology Algorithms
View on PubMed DOI

Utilizing machine learning and hemagglutinin sequences to identify likely hosts of influenza H3Nx viruses.

Preventive veterinary medicine Sep 26, 2024
Influenza is a disease that represents both a public health and agricultural risk with pandemic potential. Among the subtypes of influenza A virus, H3 influenza virus can infect many avian and mammalian species and is therefore a virus of interest to...
Machine Learning Animals Influenza in Birds Swine Influenza A Virus, H3N2 Subtype Dogs Hemagglutinin Glycoproteins, Influenza Virus Dog Diseases Birds Orthomyxoviridae Infections Swine Diseases Influenza A virus
View on PubMed DOI

Machine Learning Using Template-Based-Predicted Structure of Haemagglutinin Predicts Pathogenicity of Avian Influenza.

Journal of microbiology and biotechnology Aug 6, 2024
Deep learning presents a promising approach to complex biological classifications, contingent upon the availability of well-curated datasets. This study addresses the challenge of analyzing three-dimensional protein structures by introducing a novel ...
Computational Biology Principal Component Analysis Neuraminidase Birds Influenza A virus Deep Learning Genome, Viral Hemagglutinin Glycoproteins, Influenza Virus Hemagglutinins Neural Networks, Computer Animals Influenza in Birds Machine Learning Algorithms
View on PubMed DOI

Seasonal antigenic prediction of influenza A H3N2 using machine learning.

Nature communications May 7, 2024
Antigenic characterization of circulating influenza A virus (IAV) isolates is routinely assessed by using the hemagglutination inhibition (HI) assays for surveillance purposes. It is also used to determine the need for annual influenza vaccine update...
Hemagglutination Inhibition Tests Antigenic Variation Antigens, Viral Influenza A Virus, H3N2 Subtype Hemagglutinin Glycoproteins, Influenza Virus Influenza, Human Seasons Influenza Vaccines Humans Machine Learning
View on PubMed DOI

De novo design of protein structure and function with RFdiffusion.

Nature Jul 11, 2023
There has been considerable recent progress in designing new proteins using deep-learning methods. Despite this progress, a general deep-learning framework for protein design that enables solution of a wide range of design challenges, including de no...
Protein Binding Proteins Deep Learning Cryoelectron Microscopy Catalytic Domain Hemagglutinin Glycoproteins, Influenza Virus
View on PubMed DOI

A Deep Learning Approach for Predicting Antigenic Variation of Influenza A H3N2.

Computational and mathematical methods in medicine Oct 16, 2021
Modeling antigenic variation in influenza (flu) virus A H3N2 using amino acid sequences is a promising approach for improving the prediction accuracy of immune efficacy of vaccines and increasing the efficiency of vaccine screening. Antigenic drift a...
Influenza A Virus, H3N2 Subtype Hemagglutinin Glycoproteins, Influenza Virus Antigenic Variation Amino Acid Sequence Influenza, Human Neural Networks, Computer Antigens, Viral Deep Learning Humans Computational Biology Databases, Protein
View on PubMed DOI

Machine Learning Prediction and Experimental Validation of Antigenic Drift in H3 Influenza A Viruses in Swine.

mSphere Mar 17, 2021
The antigenic diversity of influenza A viruses (IAV) circulating in swine challenges the development of effective vaccines, increasing zoonotic threat and pandemic potential. High-throughput sequencing technologies can quantify IAV genetic diversity,...
Machine Learning Phenotype Animals Genotype Regression Analysis Swine Swine Diseases Hemagglutinin Glycoproteins, Influenza Virus Amino Acid Substitution Antigenic Variation Orthomyxoviridae Infections Influenza A Virus, H3N2 Subtype
View on PubMed DOI

Convolutional Neural Network Based Approach to in Silico Non-Anticipating Prediction of Antigenic Distance for Influenza Virus.

Viruses Sep 12, 2020
Evaluation of the antigenic similarity degree between the strains of the influenza virus is highly important for vaccine production. The conventional method used to measure such a degree is related to performing the immunological assays of hemaggluti...
Influenza, Human Influenza A Virus, H1N1 Subtype Orthomyxoviridae Neural Networks, Computer Computer Simulation Humans Antigens, Viral Amino Acid Sequence Hemagglutinin Glycoproteins, Influenza Virus
View on PubMed DOI

Conservation region finding for influenza A viruses by machine learning methods of N-linked glycosylation sites and B-cell epitopes.

Mathematical biosciences Jun 17, 2019
Influenza type A, a serious infectious disease of the human respiratory tract, poses an enormous threat to human health worldwide. It leads to high mortality rates in poultry, pigs, and humans. The primary target identity regions for the human immune...
Neuraminidase Glycosylation Viral Proteins Humans Conserved Sequence Epitopes, B-Lymphocyte Machine Learning Databases, Protein Hemagglutinin Glycoproteins, Influenza Virus Influenza A virus Influenza, Human
View on PubMed DOI
Popular Topics
Recent Journals