AIMC Topic: Neuraminidase

Clear Filters Showing 1 to 9 of 9 articles

Machine learning-assisted affinity ultrafiltration for bioactive natural products discovery:Application to screening of neuraminidase inhibitors from medicinal herbs.

Analytica chimica acta Aug 8, 2025
BACKGROUND: Bioactive natural products represent a vital resource for combating human diseases. However, their discovery often encounters multiple challenges. Bioactivity-guided isolation can yield bioactive compounds but are labor-intensive and have...
Biological Products Neuraminidase Plants, Medicinal Machine Learning Humans Influenza A Virus, H1N1 Subtype Drug Discovery Antiviral Agents Enzyme Inhibitors Ultrafiltration
View on PubMed DOI

Integrated virtual screening and compound generation targeting H275Y mutation in the neuraminidase gene of oseltamivir-resistant influenza strains.

Molecular diversity Mar 14, 2025
Neuraminidase (NA) is an essential enzyme located at the outer layer of the influenza virus and plays a key role in the release of virions from infected cells. The rising incidence of global epidemics has made the urgent need for effective antiviral ...
Molecular Dynamics Simulation Drug Evaluation, Preclinical Influenza, Human Molecular Docking Simulation Antiviral Agents Mutation Influenza A Virus, H1N1 Subtype Quantitative Structure-Activity Relationship Viral Proteins Oseltamivir Neuraminidase Drug Resistance, Viral Enzyme Inhibitors Humans
View on PubMed DOI

Machine Learning Using Template-Based-Predicted Structure of Haemagglutinin Predicts Pathogenicity of Avian Influenza.

Journal of microbiology and biotechnology Aug 6, 2024
Deep learning presents a promising approach to complex biological classifications, contingent upon the availability of well-curated datasets. This study addresses the challenge of analyzing three-dimensional protein structures by introducing a novel ...
Algorithms Animals Influenza in Birds Neural Networks, Computer Machine Learning Computational Biology Principal Component Analysis Neuraminidase Genome, Viral Birds Influenza A virus Deep Learning Hemagglutinin Glycoproteins, Influenza Virus Hemagglutinins
View on PubMed DOI

Drug Design of Targeted Chemical Libraries Based on Artificial Intelligence and Pair-Based Multiobjective Optimization.

Journal of chemical information and modeling Sep 9, 2020
Artificial intelligence and multiobjective optimization represent promising solutions to bridge chemical and biological landscapes by addressing the automated design of compounds as a result of a humanlike creative process. In the present study, we ...
Coronavirus 3C Proteases Cholinesterase Inhibitors Enzyme Inhibitors Viral Nonstructural Proteins Betacoronavirus Pneumonia, Viral Small Molecule Libraries Cysteine Endopeptidases Coronavirus Infections Neuraminidase Acetylcholinesterase Drug Design Influenza A virus Humans Antiviral Agents Neural Networks, Computer SARS-CoV-2 Artificial Intelligence Pandemics Molecular Docking Simulation COVID-19
View on PubMed DOI

Conservation region finding for influenza A viruses by machine learning methods of N-linked glycosylation sites and B-cell epitopes.

Mathematical biosciences Jun 17, 2019
Influenza type A, a serious infectious disease of the human respiratory tract, poses an enormous threat to human health worldwide. It leads to high mortality rates in poultry, pigs, and humans. The primary target identity regions for the human immune...
Humans Glycosylation Databases, Protein Machine Learning Influenza A virus Conserved Sequence Epitopes, B-Lymphocyte Hemagglutinin Glycoproteins, Influenza Virus Influenza, Human Neuraminidase Viral Proteins
View on PubMed DOI

Using Support Vector Machine (SVM) for Classification of Selectivity of H1N1 Neuraminidase Inhibitors.

Molecular informatics Jan 15, 2016
Inhibition of the neuraminidase is one of the most promising strategies for preventing influenza virus spreading. 479 neuraminidase inhibitors are collected for dataset 1 and 208 neuraminidase inhibitors for A/P/8/34 are collected for dataset 2. Usin...
Influenza A Virus, H1N1 Subtype Quantitative Structure-Activity Relationship Support Vector Machine Neuraminidase Enzyme Inhibitors Computer Simulation Antiviral Agents
View on PubMed DOI

Discovery of Influenza A virus neuraminidase inhibitors using support vector machine and Naïve Bayesian models.

Molecular diversity Dec 21, 2015
Neuraminidase (NA) is a critical enzyme in the life cycle of influenza virus, which is known as a successful paradigm in the design of anti-influenza agents. However, to date there are no classification models for the virtual screening of NA inhibito...
Influenza A Virus, H3N2 Subtype Bayes Theorem Neuraminidase Drug Discovery Enzyme Inhibitors Computational Biology Influenza A Virus, H1N1 Subtype Support Vector Machine
View on PubMed DOI

Citations alone were enough to predict favorable conclusions in reviews of neuraminidase inhibitors.

Journal of clinical epidemiology Oct 22, 2014
OBJECTIVES: To examine the use of supervised machine learning to identify biases in evidence selection and determine if citation information can predict favorable conclusions in reviews about neuraminidase inhibitors.
Selection Bias Humans Neuraminidase Artificial Intelligence Enzyme Inhibitors Review Literature as Topic Research Design Publications Influenza, Human
View on PubMed DOI

A novel reassortant avian influenza H4N6 virus isolated from an environmental sample during a surveillance in Maharashtra, India.

The Indian journal of medical research Jun 1, 2021
BACKGROUND & OBJECTIVES: Low pathogenic avian influenza (LPAI) viruses cause mild clinical illness in domestic birds. Migratory birds are a known reservoir for all subtypes of avian influenza (AI) viruses. The objective of the study was to characteri...
Influenza A virus India Neuraminidase Birds Humans Animals, Wild Animals Phylogeny Influenza in Birds
View on PubMed DOI
Popular Topics
Recent Journals