AIMC Topic: Heterocyclic Compounds, 4 or More Rings

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AI-driven discovery of antiretroviral drug bictegravir and etravirine as inhibitors against monkeypox and related poxviruses.

Communications biology Dec 2, 2025
Monkeypox virus (MPXV) caused the 2022-2023 global mpox and the concurrent outbreaks in Africa, disproportionately affecting immunocompromised individuals such as people living with HIV. With no approved treatment available, we developed a robust art...
Humans Artificial Intelligence Animals Drug Discovery Antiviral Agents Pyridones Amides Heterocyclic Compounds, 3-Ring Piperazines Anti-Retroviral Agents Mpox, Monkeypox Nitriles Pyrimidines Pyridazines Heterocyclic Compounds, 4 or More Rings Monkeypox virus Poxviridae
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Associations between weight gain, integrase inhibitors antiretroviral agents, and gut microbiome in people living with HIV: a cross-sectional study.

Scientific reports Jul 2, 2025
Dolutegravir and bictegravir are second-generation HIV integrase strand transfer inhibitors (INSTIs) that were previously associated with abnormal weight gain. This monocentric cross-sectional study investigates associations between weight gain durin...
Humans Female Adult Cross-Sectional Studies Male Middle Aged HIV Infections Gastrointestinal Microbiome Pyridones Amides Oxazines Heterocyclic Compounds, 3-Ring Piperazines Weight Gain HIV Integrase Inhibitors Heterocyclic Compounds, 4 or More Rings
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Simultaneous spectrophotometric quantitative analysis of velpatasvir and sofosbuvir in recently approved FDA pharmaceutical preparation using artificial neural networks and genetic algorithm artificial neural networks.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Jan 15, 2021
Two chemometric assisted spectrophotometric models were applied for the quantitative analysis of velpatasvir and sofosbuvir in their newly FDA approved pharmaceutical dosage form. The UV absorption spectra of velpatasvir and sofosbuvir showed certain...
Humans Neural Networks, Computer Antiviral Agents Tablets Carbamates Spectrophotometry Sofosbuvir Heterocyclic Compounds, 4 or More Rings
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