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HIV Integrase Inhibitors

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Durability of dolutegravir plus boosted darunavir as salvage or simplification of salvage regimens in HIV-1 infected, highly treatment-experienced subjects.

HIV clinical trials 30890064
BACKGROUND: Dolutegravir (DTG) plus boosted darunavir (bDRV) is a compact, adherence-friendly salvage regimen with the highest genetic barrier to HIV-1 resistance.
Adult Aged Cohort Studies Darunavir Female Heterocyclic Compounds, 3-Ring HIV Infections HIV Integrase Inhibitors HIV Protease Inhibitors HIV-1 Humans Italy Male Middle Aged Oxazines Piperazines Pyridones Reproducibility of Results Salvage Therapy
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Ligand-Based Virtual Screening in a Search for Novel Anti-HIV-1 Chemotypes.

Journal of chemical information and modeling 26431196
In a search for new anti-HIV-1 chemotypes, we developed a multistep ligand-based virtual screening (VS) protocol combining machine learning (ML) methods with the privileged structures (PS) concept. In its learning step, the VS protocol was based on H...
Anti-HIV Agents Biological Assay Cells, Cultured Drug Evaluation, Preclinical HIV Integrase Inhibitors HIV-1 Humans Inhibitory Concentration 50 Ligands Machine Learning Models, Molecular Molecular Structure
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Study of Structure-active Relationship for Inhibitors of HIV-1 Integrase LEDGF/p75 Interaction by Machine Learning Methods.

Molecular informatics 28244220
HIV-1 integrase (IN) is a promising target for anti-AIDS therapy, and LEDGF/p75 is proved to enhance the HIV-1 integrase strand transfer activity in vitro. Blocking the interaction between IN and LEDGF/p75 is an effective way to inhibit HIV replicati...
Computer Simulation HIV Integrase HIV Integrase Inhibitors Humans Intercellular Signaling Peptides and Proteins Machine Learning Models, Molecular Molecular Conformation Molecular Structure Protein Binding Reproducibility of Results ROC Curve Structure-Activity Relationship
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Classification and Design of HIV-1 Integrase Inhibitors Based on Machine Learning.

Computational and mathematical methods in medicine 33868450
A key enzyme in human immunodeficiency virus type 1 (HIV-1) life cycle, integrase (IN) aids the integration of viral DNA into the host DNA, which has become an ideal target for the development of anti-HIV drugs. A total of 1785 potential HIV-1 IN inh...
Bayes Theorem Computational Biology Databases, Pharmaceutical Decision Trees Drug Design HIV Infections HIV Integrase HIV Integrase Inhibitors HIV-1 Humans Machine Learning Molecular Structure Structure-Activity Relationship
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